Evidence map›Paper›PMID 33376574›Full record

ReviewThe World Allergy Organization journal2020

Consensus on DEfinition of Food Allergy SEverity (DEFASE): Protocol for a systematic review.

Stefania Arasi, Ulugbek Nurmatov, Paul J Turner, Ignacio J Ansotegui, Shahd Daher, Audrey Dunn-Galvin, Motohiro Ebisawa, Philippe Eigenmann, Montserrat Fernandez-Rivas, Ruchi Gupta and 10 more

Abstract readReview
In one paragraph

Review in The World Allergy Organization journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Anaphylaxis severity grade, during oral food challenges, assessed by five different classifications.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Observational
  4. Review
  5. Article
  6. Article
  7. Food labeling issues for severe food allergic patients.The World Allergy Organization journal · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Stefania ArasiPredictive and Preventive Medicine Research Unit, Multifactorial and Systemic Diseases Research Area, Pediatric Allergology Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Ulugbek NurmatovDivision of Population Medicine, School of Medicine, Cardiff University, Wales, UK.
Paul J TurnerNational Heart & Lung Institute, Imperial College London, London, UK.
Ignacio J AnsoteguiDept. Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
Shahd DaherNuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, England, UK.
Audrey Dunn-GalvinApplied Psychology and Paediatrics and Child Health, University College Cork, Cork, Ireland.
Motohiro EbisawaClinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan.
Philippe EigenmannPediatric Allergy Unit, Department of Women-Children-Teenagers Pediatrics, University Hospitals of Geneva, Geneva, Switzerland.
Montserrat Fernandez-RivasServicio de Alergia, Hospital Clınico San Carlos, UCM, IdISSC, ARADyAL, Madrid, Spain.
Ruchi GuptaCenter for Food Allergy and Asthma Research (CFAAR), Northwestern University Feinberg School of Medicine; Department of Pediatrics & Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, USA.
Anna Nowak-WegrzynAllergy and Immunology, Department of Pediatrics, New York University School of Medicine, Langone Health, New York, NY, USA.
Stavros PetrouNuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, England, UK.
Graham RobertsNIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Mario A Sánchez BorgesAllergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, Venezuela.
Sayantani B SindherDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.
Luciana Kase TannoHospital Sírio Libanês, São Paulo, Brazil.
Marta Vazquez-OrtizDepartment of Paediatrics, Imperial College, London, United Kingdom.
Brian P VickeryDepartment of Pediatrics, Emory University, Atlanta, GA, USA.
Gary Wing-Kin WongDepartment of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China.
Alessandro FiocchiPredictive and Preventive Medicine Research Unit, Multifactorial and Systemic Diseases Research Area, Pediatric Allergology Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsThe term "Food Allergy" refers to a complex global health problem with a wide spectrum of severity. However, a uniform definition of severe food allergy is currently missing. This systematic review is the preliminary step towards a state-of-the-art synopsis of the current evidence relating to the severity of IgE-mediated food allergy; it will inform attempts to develop a consensus to define food allergy severity by clinicians and other stakeholders.

methodsWe will undertake a systematic review, which will involve searching international biomedical databases for published studies. Studies will be independently screened against pre-defined eligibility criteria and critically appraised by established instruments. Data will be descriptively and, if possible and applicable, quantitatively synthesised. ETHICS AND DISSEMINATION: This study does not require any specific ethical approval since it is a systematic review. We plan to report results from this systematic review in a peer reviewed journal. These results will be used to inform the development of an international consensus to define severe food allergy. Author's potential conflicts of interest are clearly stated. PROSPERO REGISTRATION NUMBER: CRD42020183103.

Indexed as

CASP, Critical Appraisal Skills ProgrammeCBA, controlled before after studiesCCT, controlled clinical trialsCHEERS, Consolidated Health Economic Evaluation Reporting StandardsCI, confidential intervalClassificationDefinitionFAIM, food allergy independent measureFAQL, food allergy quality of lifeFARE, Food Allergy Research & EducationFood allergyGRADE, Grading of Recommendations Assessment, Development and EvaluationITS, interrupted time seriesPRISMA, Preferred Reporting Items for Systematic Reviews and Meta-AnalysesPROSPERO, Prospective Register of Systematic ReviewsRCT, randomized controlled trialsSeverityWAO, World Allergy Organization

Identifiers

PMID33376574
PMCPMC7753945

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.