Evidence map›Paper›PMID 33376499›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2020

The Metabolomic Rationale for Treating Perimenopausal Syndrome as Kidney Deficiency.

Xueqin Chen, Caiming Wu, Wen'na Liang, Jianying Shen, Zewei Zhuo, Liu Hu, Luwei Ruan, Pengheng Zhang, Leqin Xu, Chengfu Li and 9 more

Abstract read
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In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xueqin ChenThe First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361026, China.
Caiming WuState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Wen'na LiangFujian University of Traditional Chinese Medicine, Fuzhou, China.
Jianying ShenFujian University of Traditional Chinese Medicine, Fuzhou, China.
Zewei ZhuoFujian University of Traditional Chinese Medicine, Fuzhou, China.
Liu HuFujian University of Traditional Chinese Medicine, Fuzhou, China.
Luwei RuanFujian University of Traditional Chinese Medicine, Fuzhou, China.
Pengheng ZhangFujian University of Traditional Chinese Medicine, Fuzhou, China.
Leqin XuXiamen Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Xiamen, China.
Chengfu LiXiamen Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Xiamen, China.
Shengyuan LinFirst Hospital Affiliated to Fujian University of Medicine, Fuzhou, China.
Junjie LanState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Haixia RenState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Hongwei YaoSchool of Chemistry and Chemical Engineering, Xiamen, Fujian, China.
Tongjin ZhaoState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Bizhen GaoFujian University of Traditional Chinese Medicine, Fuzhou, China.ORCID https://orcid.org/0000-0002-3792-7761
Tianwei LinState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.ORCID https://orcid.org/0000-0002-9293-4673
Huiying HuangState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.ORCID https://orcid.org/0000-0002-5466-0114
Candong LiFujian University of Traditional Chinese Medicine, Fuzhou, China.ORCID https://orcid.org/0000-0003-1799-4315

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTraditional Chinese medicine (TCM) typically attributes the etiopathogenesis of perimenopausal syndrome (PMS) to kidney deficiency in the TCM stratification system for diagnosis. However, the molecular basis of this classical attribution remains to be investigated. MATERIALS AND

methodsWith naturally aged rats as a model for PMS, the metabolomic response to TCM treatment for kidney deficiency was investigated by

results

conclusionThe data support the notion that kidney deficiency is responsible, in part at least, for PMS, and the relevant prescriptions are helpful in dampening the changes in the body's metabolic states to alleviate symptoms of the disorder.

Identifiers

PMID33376499
PMCPMC7746443

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