Evidence map›Paper›PMID 33376487›Full record

ArticleInternational journal of endocrinology2020

TIR-Domain-Containing Adaptor-Inducing Interferon-

Junling Yang, Ken-Ichiro Fukuchi

Open access · goldAbstract read
In one paragraph

Article in International journal of endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Junling YangDepartment of Cancer Biology and Pharmacology, University of Illinois College of Medicine Peoria, 1 Illini Drive, Peoria, IL 61605, USA.ORCID https://orcid.org/0000-0003-1523-5067
Ken-Ichiro FukuchiDepartment of Cancer Biology and Pharmacology, University of Illinois College of Medicine Peoria, 1 Illini Drive, Peoria, IL 61605, USA.ORCID https://orcid.org/0000-0003-0009-1785
University of Illinois Urbana-Champaign · US

Funding

Modulation of innate immunity in Alzheimer diseaseR21AG062179 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FUKUCHI, KEN-ICHIRO · 2019 to 2020
$440k
Altering immune tolerance in Alzheimer diseaseR21AG064811 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FUKUCHI, KEN-ICHIRO · 2019 to 2020
$440k
Role of the MyD88-independent pathway in Alzheimers diseaseR21AG042082 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FUKUCHI, KEN-ICHIRO · 2013 to 2014
$439k
NIA NIH HHS R21 AG042082NIA NIH HHS R21 AG062179NIA NIH HHS R21 AG064811
6 · The paper itself

Abstract

Obesity significantly increases the risk of developing type 2 diabetes mellitus and other metabolic diseases. Obesity is associated with chronic low-grade inflammation in white adipose tissues, which is thought to play an essential role in developing insulin resistance. Many lines of evidence indicate that toll-like receptors (TLRs) and their downstream signaling pathways are involved in development of chronic low-grade inflammation and insulin resistance, which are associated with obesity. Mice lacking molecules positively involved in the TLR signaling pathways are generally protected from high-fat diet-induced inflammation and insulin resistance. In this study, we have determined the effects of genetic deficiency of toll/interleukin-1 receptor-domain-containing adaptor-inducing interferon-

Identifiers

PMID33376487
PMCPMC7744180
OpenAlexW3113138987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.