ArticleInternational journal of women's health2020
The Use of Single Dose Methotrexate in the Management of Ectopic Pregnancy and Pregnancy of Unknown Location: 10 Years' Experience in a Tertiary Center.
Article in International journal of women's health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Methotrexate in relatively contraindicated ectopic pregnancies: who benefits from treatment?Archives of gynecology and obstetrics · 2026Article
- Ruptured ovarian ectopic pregnancy in a primigravid woman: A case report.International journal of reproductive biomedicine · 2024Article
- Assessing the risk factors and management outcomes of ectopic pregnancy: A retrospective case-control study.International journal of reproductive biomedicine · 2023Article
- Predictors of Successful Medical Management With Methotrexate in Unruptured Tubal Ectopic Pregnancy.Cureus · 2022Article
- Future Perspectives of Ectopic Pregnancy Treatment-Review of Possible Pharmacological Methods.International journal of environmental research and public health · 2022Review
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6 authors.
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Abstract
objectiveTo study factors associated with the success of single dose methotrexate (MTX) treatment in women with ectopic pregnancy.
methodsThis is a retrospective study of women (n=110) with ectopic pregnancy and treated with single dose of MTX. The clinical presentations, transvaginal sonography (TVS) findings, pretreatment beta-human chorionic gonadotropin (β-HCG), and progesterone values were compared between the treatment success (Group S) and treatment failure (Group F) groups.
resultsThe overall success rate of treatment with single dose of MTX was 75.45%. The majority of patients in both groups presented with pain and bleeding (~55%), and bleeding only was the presenting symptom in about 20% of patients. Only 3 patients (3.61%) in Group S required a repeat dose of MTX. In contrast, 51.8% of the Group F patients required a repeat dose. The mean pretreatment β-HCG level was 2.3 times higher in Group F than in Group S (1734±1684 vs 4036±2940 IU/L). The data showed a β-HCG level of 3924IU/L as a suitable cut-off value with 76.19% sensitivity and 62.5% specificity to predict MTX treatment success. History of ectopic pregnancy had no relation with success/treatment failure or a repeat dose. None of the TVS findings were related to the outcome of the treatment, whereas pretreatment HCG level was a significant predictor.
conclusionThe single dose MTX treatment was successful in 75.45% (83/110) of cases, with 3.61% (3/83) requiring a repeat dose of the drug. Pretreatment β-HCG level is a significant predictor of the treatment outcome.
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