Evidence map›Paper›PMID 33376133›Full record

ArticleLife science alliance2021

Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse models.

Chang S Chan, Yvonne Sun, Hua Ke, Yuhan Zhao, Merzu Belete, Cen Zhang, Zhaohui Feng, Arnold J Levine, Wenwei Hu

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. SEOM clinical guideline on heritable TP53-related cancer syndrome (2022).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Guideline
  2. Article
  3. Personalized screening strategies forLancet regional health. Americas · 2025
    Article
  4. The Mouse Models of Human Cancer database (MMHCdb).Disease models & mechanisms · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chang S ChanRutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ, USA chanc3@cinj.rutgers.edu.ORCID 0000-0001-9897-4759
Yvonne SunPMV Pharma, Cranbury, NJ, USA.
Hua KeRutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ, USA.
Yuhan ZhaoRutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ, USA.ORCID 0000-0001-5529-1907
Merzu BeleteRutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ, USA.ORCID 0000-0003-0183-3170
Cen ZhangRutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ, USA.
Zhaohui FengRutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ, USA.
Arnold J LevineSimons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, USA alevine@ias.edu.ORCID 0000-0002-1871-6387
Wenwei HuRutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ, USA wh221@cinj.rutgers.edu.ORCID 0000-0003-3971-4257
Rutgers, The State University of New Jersey · USInstitute for Advanced Study · US

Funding

Scientific ReagentsP01CA087497 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI PETRINI, JOHN HJ · 2000 to 2021
$35.4M
The role of chronic stress in regulation of mutant p53 and tumorigenesisR01CA203965 · NCI · RBHS -CANCER INSTITUTE OF NEW JERSEY · PI HU, WENWEI · 2017 to 2021
$1.8M
NCI NIH HHS P01 CA087497NCI NIH HHS R01 CA203965
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Germ-Line MutationPhenotypeAnimalsCarcinogenesisDisease Models, AnimalFemaleGenetic Predisposition to DiseaseHeterozygoteLi-Fraumeni SyndromeMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred DBAMice, Inbred NODMice, TransgenicTrp53 protein, mouseTumor Suppressor Protein p53

Identifiers

PMID33376133
PMCPMC7772779
OpenAlexW3115211708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.