Evidence map›Paper›PMID 33376132›Full record

ArticleLife science alliance2021

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.

Maria Inês Alvelos, Mirko Brüggemann, Fx Reymond Sutandy, Jonàs Juan-Mateu, Maikel Luis Colli, Anke Busch, Miguel Lopes, Ângela Castela, Annemieke Aartsma-Rus, Julian König and 2 more

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Cancers · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Exploring the multifunctionality of SR proteins.Biochemical Society transactions · 2022
    Article
  10. Review
  11. Review
  12. Targeting Splicing Factor SRSF6 for Cancer Therapy.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 5 countries.

Maria Inês AlvelosULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Brussels, Belgium.ORCID 0000-0003-2897-5646
Mirko BrüggemannBuchman Institute for Molecular Life Sciences (BMLS), Goethe University Frankfurt, Frankfurt am Main, Germany.
Fx Reymond SutandyInstitute of Molecular Biology gGmbH, Mainz, Germany.
Jonàs Juan-MateuULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Brussels, Belgium.ORCID 0000-0001-9749-6441
Maikel Luis ColliULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Brussels, Belgium.ORCID 0000-0002-2200-4761
Anke BuschInstitute of Molecular Biology gGmbH, Mainz, Germany.ORCID 0000-0002-2232-1329
Miguel LopesULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Ângela CastelaULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Annemieke Aartsma-RusLeiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-1565-654X
Julian KönigInstitute of Molecular Biology gGmbH, Mainz, Germany.ORCID 0000-0002-9398-5421
Kathi ZarnackBuchman Institute for Molecular Life Sciences (BMLS), Goethe University Frankfurt, Frankfurt am Main, Germany.ORCID 0000-0003-3527-3378
Décio L EizirikULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Brussels, Belgium.ORCID 0000-0003-2453-5889
Université Libre de Bruxelles · BEInstitute of Molecular Biology · DEGoethe University Frankfurt · DELeiden University Medical Center · NL

Funding

The Integrated Stress Response in Human Islets During Early T1DU01DK127786 · NIDDK · UNIVERSITY OF CHICAGO · PI EVANS-MOLINA, CARMELLA, MIRMIRA, RAGHAVENDRA G · 2020 to 2025
$7.1M
NIDDK NIH HHS U01 DK127786
6 · The paper itself

Abstract

In pancreatic β-cells, the expression of the splicing factor SRSF6 is regulated by GLIS3, a transcription factor encoded by a diabetes susceptibility gene.

Indexed as

Gene Expression RegulationAlternative SplicingBinding SitesCell LineCell SurvivalDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2ExonsGene Knockdown TechniquesHumansInsulin-Secreting CellsLIM Domain ProteinsPhosphoproteinsProtein BindingProtein Interaction Domains and MotifsProtein Interaction MapsLIM Domain ProteinsLMO7 protein, humanPhosphoproteinsRNASerine-Arginine Splicing FactorsSRSF6 protein, humanTranscription Factors

Identifiers

PMID33376132
PMCPMC7772782
OpenAlexW3115191699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.