Evidence map›Paper›PMID 33375720›Full record

ArticleInternational journal of molecular sciences2020

Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy.

Fasih Bintang Ilhami, Kai-Chen Peng, Yi-Shiuan Chang, Yihalem Abebe Alemayehu, Hsieh-Chih Tsai, Juin-Yih Lai, Yu-Hsuan Chiao, Chen-Yu Kao, Chih-Chia Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Fasih Bintang IlhamiGraduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.ORCID 0000-0002-6048-6730
Kai-Chen PengGraduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
Yi-Shiuan ChangGraduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
Yihalem Abebe AlemayehuGraduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
Hsieh-Chih TsaiGraduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
Juin-Yih LaiGraduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
Yu-Hsuan ChiaoDepartment of Chemical Engineering, University of Arkansas, Fayetteville, AR 72701, USA.ORCID 0000-0002-2371-4095
Chen-Yu KaoGraduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.ORCID 0000-0002-7364-1584
Chih-Chia ChengGraduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.ORCID 0000-0002-1605-6338
National Taiwan University of Science and Technology · TWChung Yuan Christian University · TWUniversity of Arkansas at Fayetteville · US

Funding

Ministry of Science and Technology, Taiwan MOST 107-2221-E-011-041-MY3
6 · The paper itself

Abstract

Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular micelles (A-PPG), in order to achieve effective drug delivery combined with photo-chemotherapy. The resulting DOX/5-ALA-loaded micelles exhibited excellent light and pH-responsive behavior in aqueous solution and high drug-entrapment stability in serum-rich media. A short duration (1-2 min) of laser irradiation with visible light induced the dissociation of the DOX/5-ALA complexes within the micelles, which disrupted micellular stability and resulted in rapid, immediate release of the physically entrapped drug from the micelles. In addition, in vitro assays of cellular reactive oxygen species generation and cellular internalization confirmed the drug-loaded micelles exhibited significantly enhanced cellular uptake after visible light irradiation, and that the light-triggered disassembly of micellar structures rapidly increased the production of reactive oxygen species within the cells. Importantly, flow cytometric analysis demonstrated that laser irradiation of cancer cells incubated with DOX/5-ALA-loaded A-PPG micelles effectively induced apoptotic cell death via endocytosis. Thus, this newly developed supramolecular system may offer a potential route towards improving the efficacy of synergistic chemotherapeutic approaches for cancer.

Indexed as

Drug Delivery SystemsLightMicellesAntineoplastic AgentsCell SurvivalDelayed-Action PreparationsDrug CarriersDrug LiberationHeLa CellsHumansPhotochemotherapyPhotosensitizing AgentsReactive Oxygen SpeciesAntineoplastic AgentsDelayed-Action PreparationsDrug CarriersMicellesPhotosensitizing AgentsReactive Oxygen Speciescombination chemotherapylight-controlled drug releasephotodynamic therapyself-assemblysupramolecular micelle

Identifiers

PMID33375720
PMCPMC7795671
OpenAlexW3114271420

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.