Evidence map›Paper›PMID 33375578›Full record

ArticleCells2020

Severity of Experimental Autoimmune Uveitis Is Reduced by Pretreatment with Live Probiotic

Otakar Dusek, Alena Fajstova, Aneta Klimova, Petra Svozilkova, Tomas Hrncir, Miloslav Kverka, Stepan Coufal, Johan Slemin, Helena Tlaskalova-Hogenova, John V Forrester and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
  5. Role of gut microbiomes in different ocular pathologies: A systematic review.World journal of gastrointestinal pathophysiology · 2025
    Article
  6. Article
  7. Review
  8. Experimental model of primary intraocular lymphoma based on BALB/CaNn strain and A20 cells is optimal for investigational research.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2025
    Article
  9. Review
  10. Review
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  12. Article
  13. Article
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  15. Article
  16. Lysate ofFrontiers in immunology · 2024
    Article
  17. Article
  18. Review
  19. Targeting the Gut-Eye Axis: An Emerging Strategy to Face Ocular Diseases.International journal of molecular sciences · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Otakar DusekDepartment of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 08 Prague, Czech Republic.
Alena FajstovaInstitute of Microbiology of the Czech Academy of Sciences, v.v.i., 142 20 Prague, Czech Republic.
Aneta KlimovaDepartment of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 08 Prague, Czech Republic.
Petra SvozilkovaDepartment of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 08 Prague, Czech Republic.ORCID 0000-0002-9221-0210
Tomas HrncirInstitute of Microbiology of the Czech Academy of Sciences, v.v.i., 549 22 Novy Hradek, Czech Republic.ORCID 0000-0001-6073-2412
Miloslav KverkaInstitute of Microbiology of the Czech Academy of Sciences, v.v.i., 142 20 Prague, Czech Republic.ORCID 0000-0002-1335-5252
Stepan CoufalInstitute of Microbiology of the Czech Academy of Sciences, v.v.i., 142 20 Prague, Czech Republic.ORCID 0000-0001-6950-1813
Johan SleminInstitute of Microbiology of the Czech Academy of Sciences, v.v.i., 142 20 Prague, Czech Republic.
Helena Tlaskalova-HogenovaInstitute of Microbiology of the Czech Academy of Sciences, v.v.i., 142 20 Prague, Czech Republic.
John V ForresterSection of Immunology and Infection, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB24 3FX, UK.
Jarmila HeissigerovaDepartment of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 08 Prague, Czech Republic.ORCID 0000-0002-2614-4681
Czech Academy of Sciences · CZCharles University · CZLions Eye Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-infectious uveitis is considered an autoimmune disease responsible for a significant burden of blindness in developed countries and recent studies have linked its pathogenesis to dysregulation of the gut microbiota. We tested the immunomodulatory properties of two probiotics,

Indexed as

Escherichia coliProbioticsAnimalsAutoimmune DiseasesDisease Models, AnimalFemaleInflammationIntestinal MucosaMiceMice, Inbred C57BLUveitisEscherichia coli Nissle 1917experimental autoimmune uveitismacrophagesmucosal immune systemprobiotics

Identifiers

PMID33375578
PMCPMC7823395
OpenAlexW3115888233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.