Evidence map›Paper›PMID 33375568›Full record

ReviewBiology2020

Revisiting the Teleost Thymus: Current Knowledge and Future Perspectives.

Felipe Barraza, Ruth Montero, Valentina Wong-Benito, Héctor Valenzuela, Carlos Godoy-Guzmán, Fanny Guzmán, Bernd Köllner, Tiehui Wang, Christopher J Secombes, Kevin Maisey and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Zebrafish as a Model for Translational Immuno-Oncology.Journal of personalized medicine · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Article
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Felipe BarrazaLaboratory of Immunology, Center of Aquatic Biotechnology, Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Av. Bernardo O'Higgins, Estación Central, Santiago 3363, Chile.
Ruth MonteroFriedrich-Loeffler-Institute, Federal Research Institute for Animal Health, 17493 Greifswald, Insel Riems, Germany.
Valentina Wong-BenitoLaboratory of Immunology, Center of Aquatic Biotechnology, Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Av. Bernardo O'Higgins, Estación Central, Santiago 3363, Chile.
Héctor ValenzuelaLaboratory of Immunology, Center of Aquatic Biotechnology, Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Av. Bernardo O'Higgins, Estación Central, Santiago 3363, Chile.
Carlos Godoy-GuzmánCenter for Biomedical and Applied Research (CIBAP), School of Medicine, Faculty of Medical Sciences, Av. Bernardo O'Higgins, Estación Central, Santiago 3363, Chile.ORCID 0000-0001-8451-7047
Fanny GuzmánNúcleo Biotecnología Curauma, Pontificia Universidad Católica de Valparaíso, Valparaíso 2373223, Chile.ORCID 0000-0002-7829-0568
Bernd KöllnerFriedrich-Loeffler-Institute, Federal Research Institute for Animal Health, 17493 Greifswald, Insel Riems, Germany.
Tiehui WangScottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK.
Christopher J SecombesScottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK.
Kevin MaiseyLaboratory of Comparative Immunology, Center of Aquatic Biotechnology, Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Av. Bernardo O'Higgins, Estación Central, Santiago 3363, Chile.
Mónica ImaraiLaboratory of Immunology, Center of Aquatic Biotechnology, Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Av. Bernardo O'Higgins, Estación Central, Santiago 3363, Chile.ORCID 0000-0001-8767-9180
Universidad Bernardo O'Higgins · CLFriedrich-Loeffler-Institut · DEUniversity of Aberdeen · GBPontificia Universidad Católica de Valparaíso · CL

Funding

Fondo Nacional de Desarrollo Científico y Tecnológico 1161510, 1201664, 11171057RCUK-CONICYT MR/N02625X/1, BB/N0240521/1Scholarship Program Becas Chile-DAAD: Doctoral scholarship with bilateral agreement abroad CONICYT-DAAD Convocatoria 2016USA VRIDEI / DICYT-USACH USA1899 VRIDEI / DICYT-USACH 021943IB-PAP
6 · The paper itself

Abstract

The thymus in vertebrates plays a critical role in producing functionally competent T-lymphocytes. Phylogenetically, the thymus emerges early during evolution in jawed cartilaginous fish, and it is usually a bilateral organ placed subcutaneously at the dorsal commissure of the operculum. In this review, we summarize the current understanding of the thymus localization, histology studies, cell composition, and function in teleost fishes. Furthermore, we consider environmental factors that affect thymus development, such as seasonal changes, photoperiod, water temperature fluctuations and hormones. Further analysis of the thymus cell distribution and function will help us understand how key stages for developing functional T cells occur in fish, and how thymus dynamics can be modulated by external factors like photoperiod. Overall, the information presented here helps identify the knowledge gaps and future steps needed for a better understanding of the immunobiology of fish thymus.

Indexed as

CD4 T cellsCD8 T cellsrainbow troutteleostthymus

Identifiers

PMID33375568
PMCPMC7824517
OpenAlexW3114912320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.