Evidence map›Paper›PMID 33375484›Full record

ArticleJournal of personalized medicine2020

Identification of a Circulating miRNA Signature to Stratify Acute Respiratory Distress Syndrome Patients.

Gennaro Martucci, Antonio Arcadipane, Fabio Tuzzolino, Giovanna Occhipinti, Giovanna Panarello, Claudia Carcione, Eleonora Bonicolini, Chiara Vitiello, Roberto Lorusso, Pier Giulio Conaldi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Gennaro MartucciAnesthesia and Intensive Care Department, IRCCS-ISMETT, 90133 Palermo, Italy.ORCID 0000-0001-8443-2414
Antonio ArcadipaneAnesthesia and Intensive Care Department, IRCCS-ISMETT, 90133 Palermo, Italy.
Fabio TuzzolinoResearch Department, IRCCS-ISMETT, 90133 Palermo, Italy.ORCID 0000-0003-2058-2135
Giovanna OcchipintiAnesthesia and Intensive Care Department, IRCCS-ISMETT, 90133 Palermo, Italy.
Giovanna PanarelloAnesthesia and Intensive Care Department, IRCCS-ISMETT, 90133 Palermo, Italy.
Claudia CarcioneFondazione Ri.MED, 90133 Palermo, Italy.
Eleonora BonicoliniAnesthesia and Intensive Care Department, IRCCS-ISMETT, 90133 Palermo, Italy.
Chiara VitielloAnesthesia and Intensive Care Department, IRCCS-ISMETT, 90133 Palermo, Italy.
Roberto LorussoCardio-Thoracic Surgery Department Heart and Vascular Centre, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.
Pier Giulio ConaldiResearch Department, IRCCS-ISMETT, 90133 Palermo, Italy.
Vitale MiceliResearch Department, IRCCS-ISMETT, 90133 Palermo, Italy.ORCID 0000-0001-8922-9909
Istituti di Ricovero e Cura a Carattere Scientifico · ITMaastricht University Medical Centre · NLRi.MED · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a need to improve acute respiratory distress syndrome (ARDS) diagnosis and management, particularly with extracorporeal membrane oxygenation (ECMO), and different biomarkers have been tested to implement a precision-focused approach. We included ARDS patients on veno-venous (V-V) ECMO in a prospective observational pilot study. Blood samples were obtained before cannulation, and screened for the expression of 754 circulating microRNA (miRNAs) using high-throughput qPCR and hierarchical cluster analysis. The miRNet database was used to predict target genes of deregulated miRNAs, and the DIANA tool was used to identify significant enrichment pathways. A hierarchical cluster of 229 miRNAs (identified after quality control screening) produced a clear separation of 11 patients into two groups: considering the baseline SAPS II, SOFA, and RESP score cluster A (

Indexed as

ARDS subphenotypesinflammationlung injurymiRNAsmiRNA signature

Identifiers

PMID33375484
PMCPMC7824233
OpenAlexW3113878105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.