Evidence map›Paper›PMID 33375460›Full record

ArticleBiomolecules2020

A Computational Approach to Explore the Interaction of Semisynthetic Nitrogenous Heterocyclic Compounds with the SARS-CoV-2 Main Protease.

Alejandro Llanes, Héctor Cruz, Viet D Nguyen, Oleg V Larionov, Patricia L Fernández

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Screening for candidate genes and cell populations associated with atherosclerotic calcification using single-cell RNA sequencing.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
  2. Article
  3. In Silico Design of New Dual Inhibitors of SARS-CoV-2 MInternational journal of molecular sciences · 2023
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Alejandro LlanesCentro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber, Panama 0801, Panama.ORCID 0000-0002-6949-2782
Héctor CruzCentro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber, Panama 0801, Panama.
Viet D NguyenDepartment of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.
Oleg V LarionovDepartment of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.
Patricia L FernándezCentro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber, Panama 0801, Panama.ORCID 0000-0002-0762-0566
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología · PAThe University of Texas at San Antonio · US

Funding

Sistema Nacional de Investigación, Secretaría Nacional de Ciencia, Tecnología e Innovación SNI-142-2018Welch Foundation AX-1788
6 · The paper itself

Abstract

In the context of the ongoing coronavirus disease 2019 (COVID-19) pandemic, numerous attempts have been made to discover new potential antiviral molecules against its causative agent, SARS-CoV-2, many of which focus on its main protease (M

Indexed as

Coronavirus 3C ProteasesCOVID-19COVID-19 Drug TreatmentMolecular Dynamics SimulationPandemicsAntiviral AgentsCatalytic DomainHeterocyclic CompoundsHumansProtease InhibitorsSARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesHeterocyclic CompoundsProtease Inhibitorsmain proteasemolecular docking simulationSARS-CoV-2semisynthetic compounds

Identifiers

PMID33375460
PMCPMC7824519
OpenAlexW3117948479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.