ArticleInternational journal of molecular sciences2020
Initiators of Classical and Lectin Complement Pathways Are Differently Engaged after Traumatic Brain Injury-Time-Dependent Changes in the Cortex, Striatum, Thalamus and Hippocampus in a Mouse Model.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- CSF1R and IL1R1 inhibitors synergistically attenuate the early pathogenesis of traumatic brain injury in mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Detection of abnormal cortex in patients with orbital fractures.Scientific reports · 2025Article
- Aging Effects on Lipid Metabolism in Response to Traumatic Brain Injury.Journal of neurochemistry · 2025Article
- T Cell Involvement in Neuroinflammation After Traumatic Brain Injury: Implications for Therapeutic Intervention.CNS neuroscience & therapeutics · 2025Review
- High-dimensional proteomic analysis for pathophysiological classification of traumatic brain injury.Brain : a journal of neurology · 2025Article
- C1q and central nervous system disorders.Frontiers in immunology · 2023Review
- Elevated Serum Complement C1q Levels After Traumatic Brain Injury and Its Association with Poor Prognosis.Neuropsychiatric disease and treatment · 2022Article
- Protein Expression of the Microglial Marker Tmem119 Decreases in Association With Morphological Changes and Location in a Mouse Model of Traumatic Brain Injury.Frontiers in cellular neuroscience · 2022Article
- Tandem Mass Tag (TMT) Quantitative Proteomic Analysis of Serum Exosomes in Cerebral Small-vessel Disease (CSVD) Patients With Depressive Symptoms.Current neurovascular research · 2022Article
- Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study.Acta neuropathologica communications · 2021Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The complement system is involved in promoting secondary injury after traumatic brain injury (TBI), but the roles of the classical and lectin pathways leading to complement activation need to be clarified. To this end, we aimed to determine the ability of the brain to activate the synthesis of classical and lectin pathway initiators in response to TBI and to examine their expression in primary microglial cell cultures. We have modeled TBI in mice by controlled cortical impact (CCI), a clinically relevant experimental model. Using Real-time quantitative polymerase chain reaction (RT-qPCR) we analyzed the expression of initiators of classical the complement component 1q, 1r and 1s (
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