Evidence map›Paper›PMID 33375167›Full record

Observational studyGenes2020

Ricardo D González, Iva Gomes, Catarina Gomes, Rita Rocha, Luís Durães, Patrícia Sousa, Manuel Figueruelo, Maria Rodríguez, Carmen Pita, Roberto Hornero and 4 more

Registry-linked trialOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06275243 (Alzheimer's Disease as a Sociosanitary Priority), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06275243 nacompletednot on this mapstarted 2022, after this paper: background citation

Alzheimer's Disease as a Sociosanitary Priority: ApoE Gene Polymorphism

TypeinterventionalSponsorUniversidad de LeónRan2022 to 2024Enrolled511ConditionsAlzheimer DiseaseArmsKit Buccal swab collection & stabilization de Canvax®, Cholesterol levels according to ApoE Genotype, Assessing cardiovascular risk factors in all participants
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Ricardo D GonzálezIPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal.ORCID 0000-0003-1706-6092
Iva GomesIPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal.
Catarina GomesIPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal.ORCID 0000-0002-1194-0941
Rita RochaIPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal.
Luís DurãesAssociação Portuguesa de Familiares e Amigos de Doentes de Alzheimer, 4455-301 Lavra, Portugal.
Patrícia SousaAssociação Portuguesa de Familiares e Amigos de Doentes de Alzheimer, 4455-301 Lavra, Portugal.
Manuel FiguerueloAsociación de Familiares y Amigos de Enfermos de Alzheimer y Otras Demencias de Zamora, 49021 Zamora, Spain.
Maria RodríguezAsociación de Familiares y Amigos de Enfermos de Alzheimer y Otras Demencias de Zamora, 49021 Zamora, Spain.
Carmen PitaAsociación de Familiares y Amigos de Enfermos de Alzheimer y Otras Demencias de Zamora, 49021 Zamora, Spain.
Roberto HorneroGrupo de Ingeniería Biomédica, Universidad de Valladolid, 47011 Valladolid, Spain.ORCID 0000-0001-9915-2570
Carlos GómezGrupo de Ingeniería Biomédica, Universidad de Valladolid, 47011 Valladolid, Spain.ORCID 0000-0002-9488-0605
Alexandra M LopesIPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal.
Nádia PintoIPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal.ORCID 0000-0002-1903-4206
Sandra MartinsIPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal.
Universidade do Porto · PTFundación INTRAS · ESOrdem dos Médicos · PTUniversidad de Valladolid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The primary genetic risk factor for late onset Alzheimer's disease (LOAD) is the

Indexed as

Genetic Predisposition to DiseaseAgedAged, 80 and overAllelesAlzheimer DiseaseApolipoproteins ECase-Control StudiesFemaleGene FrequencyHealthy VolunteersHumansMaleMiddle AgedPolymorphism, Single NucleotideSpainApoE protein, humanApolipoproteins EApolipoprotein E (APOE)disease risklate onset Alzheimer’s disease (LOAD)rs429358rs7412sanger sequencing

Identifiers

PMID33375167
PMCPMC7822120
OpenAlexW3113386813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.