Evidence map›Paper›PMID 33375115›Full record

ArticleBiomolecules2020

Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and

Jan Konecny, Anna Misiachna, Martina Hrabinova, Lenka Pulkrabkova, Marketa Benkova, Lukas Prchal, Tomas Kucera, Tereza Kobrlova, Vladimir Finger, Marharyta Kolcheva and 6 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cholinesterase Research.Biomolecules · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Jan KonecnyDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
Anna MisiachnaInstitute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic.
Martina HrabinovaDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.ORCID 0000-0002-9428-4109
Lenka PulkrabkovaDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
Marketa BenkovaBiomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
Lukas PrchalBiomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
Tomas KuceraDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
Tereza KobrlovaBiomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
Vladimir FingerBiomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
Marharyta KolchevaInstitute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic.
Stepan KortusInstitute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic.
Daniel JunDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
Marian ValkoSlovak University of Technology, Faculty of Chemical and Food Technology, Radlinskeho 9, 812 37 Bratislava, Slovakia.
Martin HorakInstitute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic.
Ondrej SoukupDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
Jan KorabecnyDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
University Hospital Hradec Králové · CZCzech Academy of Sciences · CZCharles University · CZSlovak University of Technology in Bratislava · SK

Funding

Agentura Pro Zdravotnický Výzkum České Republiky NU20-08-00296Charles University SVV 260 547"e-Infrastruktura CZ" INFRA LM2018140European Regional Development Fund: Project "PharmaBrain" CZ.02.1.01/0.0/0.0/16_025/0007444Faculty of Military Health Sciences, University of Defence FVZ201803Faculty of Military Health Sciences, University of Defence Long-term development planMH CZ - DRO 00179906
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a complex disorder with unknown etiology. Currently, only symptomatic therapy of AD is available, comprising cholinesterase inhibitors and

Indexed as

Alzheimer DiseaseAnimalsBlood-Brain BarrierButyrylcholinesteraseCHO CellsCholinesterase InhibitorsComputer SimulationCricetulusEnzyme InhibitorsFluorenesHumansReceptors, N-Methyl-D-AspartateButyrylcholinesteraseCholinesterase InhibitorsEnzyme InhibitorsfluoreneFluorenesNR2B NMDA receptorReceptors, N-Methyl-D-AspartateacetylcholinesteraseAlzheimer’s diseasebutyrylcholinesterasefluorenein silicoin vitromulti-target directed ligandsN-methyl-d-aspartate receptor

Identifiers

PMID33375115
PMCPMC7822176
OpenAlexW3114027033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.