ArticleMicromachines2020
Acoustic Cell Patterning in Hydrogel for Three-Dimensional Cell Network Formation.
Article in Micromachines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- A Systematic Review on Artificial Liver for Implantation.Journal of functional biomaterials · 2026Review
- Ultrasound-responsive hydrogels for bone and cartilage tissue engineering.Materials today. Bio · 2025Review
- Improved acoustic holograms using simulated annealing.Biomicrofluidics · 2025Article
- Sacrificing Alginate in Decellularized Extracellular Matrix Scaffolds for Implantable Artificial Livers.Journal of functional biomaterials · 2025Article
- Programmable Acoustic Holography using Medium-Sound-Speed Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Acoustic and Magnetic Stimuli-Based Three-Dimensional Cell Culture Platform for Tissue Engineering.Tissue engineering and regenerative medicine · 2023Review
- Phase holograms for the three-dimensional patterning of unconstrained microparticles.Scientific reports · 2023Article
- A simple acoustofluidic device for on-chip fabrication of PLGA nanoparticles.Biomicrofluidics · 2022Article
- Angiogenesis in Free-Standing Two-Vasculature-Embedded Scaffold Extruded by Two-Core Laminar Flow Device.International journal of bioprinting · 2022Article
- Acoustofluidics for simultaneous nanoparticle-based drug loading and exosome encapsulation.Microsystems & nanoengineering · 2022Article
- Development and Utilization of Multifunctional Polymeric Scaffolds for the Regulation of Physical Cellular Microenvironments.Polymers · 2021Review
- Recent progress in acoustic field-assisted 3D-printing of functional composite materials.MRS advances · 2021Article
- Ultrasonic Particle Manipulation in Glass Capillaries: A Concise Review.Micromachines · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
In the field of engineered organ and drug development, three-dimensional network-structured tissue has been a long-sought goal. This paper presents a direct hydrogel extrusion process exposed to an ultrasound standing wave that aligns fibroblast cells to form a network structure. The frequency-shifted (2 MHz to 4 MHz) ultrasound actuation of a 400-micrometer square-shaped glass capillary that was continuously perfused by fibroblast cells suspended in sodium alginate generated a hydrogel string, with the fibroblasts aligned in single or quadruple streams. In the transition from the one-cell stream to the four-cell streams, the aligned fibroblast cells were continuously interconnected in the form of a branch and a junction. The ultrasound-exposed fibroblast cells displayed over 95% viability up to day 10 in culture medium without any significant difference from the unexposed fibroblast cells. This acoustofluidic method will be further applied to create a vascularized network by replacing fibroblast cells with human umbilical vein endothelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.