Drug Resistance in Filarial Parasites Does Not Affect Mosquito Vectorial Capacity.

Erik Neff, Christopher C Evans, Pablo D Jimenez Castro, Ray M Kaplan, Guha Dharmarajan

Open access · goldAbstract read

In one paragraph

Article in Pathogens (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 51% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

Current issues in heartworm chemotherapy.Parasites & vectors · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Erik NeffSavannah River Ecology Laboratory, University of Georgia, Drawer E, Aiken, SC 29802, USA.ORCID 0000-0002-5521-5629

Christopher C EvansDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Pablo D Jimenez CastroDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0001-5596-7380

Ray M KaplanDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Guha DharmarajanSavannah River Ecology Laboratory, University of Georgia, Drawer E, Aiken, SC 29802, USA.ORCID 0000-0001-8500-0429

University of Georgia · US

Funding

U.S. Department of Energy Financial Assistance Award DE-EM0004391

6 · The paper itself

Abstract

Parasite drug resistance presents a major obstacle to controlling and eliminating vector-borne diseases affecting humans and animals. While vector-borne disease dynamics are affected by factors related to parasite, vertebrate host and vector, research on drug resistance in filarial parasites has primarily focused on the parasite and vertebrate host, rather than the mosquito. However, we expect that the physiological costs associated with drug resistance would reduce the fitness of drug-resistant vs. drug-susceptible parasites in the mosquito wherein parasites are not exposed to drugs. Here we test this hypothesis using four isolates of the dog heartworm (

Indexed as

Aedes spp.arthropodDirofilaria immitisdisease transmissiondrug resistanceextrinsic incubation periodfilariamacrocyclic lactonesmosquitovector competence

Identifiers

PMID33375024

DOI10.3390/pathogens10010002

PMCPMC7822010

OpenAlexW3115288256

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.