Evidence map›Paper›PMID 33374959›Full record

ArticleInternational journal of molecular sciences2020

The Effect of Chronic Mild Stress and Escitalopram on the Expression and Methylation Levels of Genes Involved in the Oxidative and Nitrosative Stresses as Well as Tryptophan Catabolites Pathway in the Blood and Brain Structures.

Paulina Wigner, Ewelina Synowiec, Paweł Jóźwiak, Piotr Czarny, Michał Bijak, Katarzyna Białek, Janusz Szemraj, Piotr Gruca, Mariusz Papp, Tomasz Śliwiński

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Keap1-Inhibitory Peptides fromMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Tryptophan in Nutrition and Health.International journal of molecular sciences · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Paulina WignerLaboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Ewelina SynowiecLaboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Paweł JóźwiakDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Piotr CzarnyDepartment of Medical Biochemistry, Medical University of Lodz, 90-647 Lodz, Poland.
Michał BijakBiohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.ORCID 0000-0002-7838-4097
Katarzyna BiałekLaboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Janusz SzemrajDepartment of Medical Biochemistry, Medical University of Lodz, 90-647 Lodz, Poland.
Piotr GrucaInstitute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland.
Mariusz PappInstitute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland.
Tomasz ŚliwińskiLaboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.ORCID 0000-0001-8385-7744
University of Łódź · PLMaj Institute of Pharmacology · PLMedical University of Lodz · PL

Funding

National Science Centre of Poland 2015/19/BNZ7/00410
6 · The paper itself

Abstract

Previous studies suggest that depression may be associated with reactive oxygen species overproduction and disorders of the tryptophan catabolites pathway. Moreover, one-third of patients do not respond to conventional pharmacotherapy. Therefore, the study investigates the molecular effect of escitalopram on the expression of

Indexed as

AnimalsAntidepressive Agents, Second-GenerationBrainCatalaseChronic DiseaseCitalopramDepressionDNA MethylationGene Expression RegulationGlutathione PeroxidaseGlutathione Peroxidase GPX1Leukocytes, MononuclearMaleMetabolic Networks and PathwaysNitric Oxide Synthase Type INitrosative StressAntidepressive Agents, Second-GenerationCatalaseCitalopramGlutathione PeroxidaseGlutathione Peroxidase GPX1Gpx1 protein, ratNitric Oxide Synthase Type ITryptophanTryptophan Hydroxylasechronic mild stressdepressionescitalopramexpressionmethylationoxidative stresstryptophan catabolites pathway

Identifiers

PMID33374959
PMCPMC7792593
OpenAlexW3113602856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.