Evidence map›Paper›PMID 33374878›Full record

ArticlePolymers2020

In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation.

Seung Kyun Yoon, Jin Ho Yang, Hyun Tae Lim, Young-Wook Chang, Muhammad Ayyoob, Xin Yang, Young Jun Kim, Han-Seung Ko, Jae Young Jho, Dong June Chung

Abstract read
In one paragraph

Article in Polymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Seung Kyun YoonSchool of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi 16419, Korea.
Jin Ho YangDepartment of Materials & Chemical Engineering, Hanyang University, 55 Hanyangdaehak-Ro, Sangnok-Gu, Ansan, Gyeonggi 15588, Korea.
Hyun Tae LimDepartment of Materials & Chemical Engineering, Hanyang University, 55 Hanyangdaehak-Ro, Sangnok-Gu, Ansan, Gyeonggi 15588, Korea.
Young-Wook ChangDepartment of Materials & Chemical Engineering, Hanyang University, 55 Hanyangdaehak-Ro, Sangnok-Gu, Ansan, Gyeonggi 15588, Korea.
Muhammad AyyoobSchool of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi 16419, Korea.ORCID 0000-0003-2055-9613
Xin YangSchool of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi 16419, Korea.
Young Jun KimSchool of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi 16419, Korea.ORCID 0000-0001-8859-1826
Han-Seung KoSchool of Chemical and Biological Engineering, Seoul National University,1 Gwanak-Ro, Gwanak-Gu, Seoul 08826, Korea.
Jae Young JhoSchool of Chemical and Biological Engineering, Seoul National University,1 Gwanak-Ro, Gwanak-Gu, Seoul 08826, Korea.
Dong June ChungSchool of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi 16419, Korea.

Funding

Ministry of Trade, Industry, and Energy (MOTIE,Korea) Project No. 10077004
6 · The paper itself

Abstract

Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA-PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials.

Indexed as

bioresorbablecompositein vivo degradation testMTT assayPGA–PLA block copolymer

Identifiers

PMID33374878
PMCPMC7794712

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.