ReviewMicroorganisms2020
The Use of Probiotics to Fight Biofilms in Medical Devices: A Systematic Review and Meta-Analysis.
Review in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Harnessing probiotics against candidiasis: a systematic review of experimental and mechanistic evidence.Frontiers in cellular and infection microbiology · 2026Pooled it
- Lactobacillus strains in the prevention and disruption of antimicrobial-resistance in pathogenic microbial biofilms: a review of mechanisms and clinical perspective.Folia microbiologica · 2026Review
- Review
- Biosurfactants as Antibiofilm Agents for Medical Devices: Mechanisms, Evidence and Integration into Infection Prevention and Control.Microorganisms · 2026Review
- Phage as control strategy against the foodborne pathogen, Bacillus cereus.Archives of microbiology · 2026Review
- Screening and Probiotic Property Analysis of High Exopolysaccharide-Producing Lactic Acid Bacteria from Sayram Yogurt.Microorganisms · 2026Article
- OvercomingFrontiers in antibiotics · 2026Review
- Amalgamation of Biofilms and Synthetic Biology: A Paradigm Shift in Biotechnology.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Review
- Bactericidal, Anti-Biofilm, and Stress-Response Modulatory Effects ofFoods (Basel, Switzerland) · 2025Article
- The clinical praxis of bacteriocins as natural anti-microbial therapeutics.Archives of microbiology · 2024Review
- Advances in Microbial Exopolysaccharides: Present and Future Applications.Biomolecules · 2024Review
- Molecular Mechanisms of Intestinal Protection byMicroorganisms · 2024Article
- Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains against Oral Pathogens.Microorganisms · 2024Article
- Protective Effect of Probiotics againstInternational journal of molecular sciences · 2024Article
- Genomic and phenotypic characterisation of Enterococcus mundtii AM_AQ_BC8 for its anti-biofilm, antimicrobial and probiotic potential.Archives of microbiology · 2024Article
- Use of Probiotics to Control Biofilm Formation in Food Industries.Antibiotics (Basel, Switzerland) · 2023Review
- Effect of Probiotics on Host-Microbiota in Bacterial Infections.Pathogens (Basel, Switzerland) · 2022Review
- Antifouling Performance of Carbon-Based Coatings for Marine Applications: A Systematic Review.Antibiotics (Basel, Switzerland) · 2022Review
- Inhibition of In VitroMicroorganisms · 2022Article
- Bioprospecting the Antibiofilm and Antimicrobial Activity of Soil and Insect Gut Bacteria.Molecules (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Medical device-associated infections (MDAI) are a critical problem due to the increasing usage of medical devices in the aging population. The inhibition of biofilm formation through the use of probiotics has received attention from the medical field in the last years. However, this sparse knowledge has not been properly reviewed, so that successful strategies for biofilm management can be developed. This study aims to summarize the relevant literature about the effect of probiotics and their metabolites on biofilm formation in medical devices using a PRISMA-oriented (Preferred Reporting Items for Systematic reviews and Meta-Analyses) systematic search and meta-analysis. This approach revealed that the use of probiotics and their products is a promising strategy to hinder biofilm growth by a broad spectrum of pathogenic microorganisms. The meta-analysis showed a pooled effect estimate for the proportion of biofilm reduction of 70% for biosurfactants, 76% for cell-free supernatants (CFS), 77% for probiotic cells and 88% for exopolysaccharides (EPS). This review also highlights the need to properly analyze and report data, as well as the importance of standardizing the in vitro culture conditions to facilitate the comparison between studies. This is essential to increase the predictive value of the studies and translate their findings into clinical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.