ArticleBiosensors2020
Molecularly Imprinted Polyscopoletin for the Electrochemical Detection of the Chronic Disease Marker Lysozyme.
Article in Biosensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- Electropolymerized Molecularly Imprinted Polymers Supported on Carbon-Based Materials for (Bio)sensing: Direct and Indirect Detection Strategies.Biosensors · 2026Review
- Progress and Perspectives of Molecular Imprinting Methods in the Development of Electrochemical Protein Biosensors.Biosensors · 2026Review
- Development of an Electrochemical Sensor Based on Molecularly Imprinted Polymer Using Functionalized Gold Nanoparticles for Caffeine Quantification.Biosensors · 2025Article
- Review
- Optical fiber sensor based on Lossy-mode resonance for tamoxifen detection and sensing applications.Scientific reports · 2025Article
- Visible-Light Photo-Iniferter Polymerization of Molecularly Imprinted Polymers for Direct Integration with Nanotransducers.Small methods · 2025Article
- A Molecularly Imprinted Polymer-Based Porous Silicon Optical Sensor for Quercetin Detection in Wines.ACS applied materials & interfaces · 2025Article
- Effect of Various Carbon Electrodes on MIP-Based Sensing Proteins Using Poly(Scopoletin): A Case Study of Ferritin.Biomimetics (Basel, Switzerland) · 2024Article
- Insights into Plastic Degradation Processes in Marine Environment by X-ray Photoelectron Spectroscopy Study.International journal of molecular sciences · 2024Article
- Green Synthesis of a Molecularly Imprinted Polymer Based on a Novel Thiophene-Derivative for Electrochemical Sensing.Molecules (Basel, Switzerland) · 2024Article
- Nanozymes based on octahedral platinum nanocrystals with {111} surface facets: glucose oxidase mimicking activity in electrochemical sensors.Mikrochimica acta · 2023Article
- Electrochemical sensing of macromolecules based on molecularly imprinted polymers: challenges, successful strategies, and opportunities.Analytical and bioanalytical chemistry · 2022Review
- Molecularly Imprinted Polymer-Based Sensors for SARS-CoV-2: Where Are We Now?Biomimetics (Basel, Switzerland) · 2022Review
- Artificial Biomimetic Electrochemical Assemblies.Biosensors · 2022Review
- An insight into polyscopoletin electrosynthesis by a quality-by-design approach.Journal of materials science · 2022Article
- Temperature-Responsive Magnetic Nanoparticles for Bioanalysis of Lysozyme in Urine Samples.Nanomaterials (Basel, Switzerland) · 2021Article
- Biomimetic Sensors to Detect Bioanalytes in Real-Life Samples Using Molecularly Imprinted Polymers: A Review.Sensors (Basel, Switzerland) · 2021Review
- Molecularly Imprinted Magnetic Fluorescent Nanocomposite-Based Sensor for Selective Detection of Lysozyme.Nanomaterials (Basel, Switzerland) · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein we report the electropolymerization of a scopoletin based molecularly imprinted polymer (MIP) for the detection of lysozyme (Lyz), an enzymatic marker of several diseases in mammalian species. Two different approaches have been used for the imprinting of lysozyme based, respectively, on the use of a monomer-template mixture and on the covalent immobilization of the enzyme prior to polymer synthesis. In the latter case, a multi-step protocol has been exploited with preliminary functionalization of gold electrode with amino groups, via 4-aminothiophenol, followed by reaction with glutaraldehyde, to provide a suitable linker for lysozyme. Each step of surface electrode modification has been followed by cyclic voltammetry and electrochemical impedance spectroscopy, which has been also employed to test the electrochemical responses of the developed MIP. The sensors show good selectivity to Lyz and detect the enzyme at concentrations up to 292 mg/L (20 μM), but with different performances, depending on the used imprinting approach. An imprinting factor equal to 7.1 and 2.5 and a limit of detection of 0.9 mg/L (62 nM) and 2.1 mg/L (141 nM) have been estimated for MIPs prepared with and without enzyme immobilization, respectively. Competitive rebinding experiment results show that this sensing material is selective for Lyz determination. Tests were performed using synthetic saliva to evaluate the potential application of the sensors in real matrices for clinical purposes.
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