ArticleBrain sciences2020
Aerobic Exercise Prevents Depression via Alleviating Hippocampus Injury in Chronic Stressed Depression Rats.
Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Improved schizophrenia detection using structural MRI with multi-scale transform and deep orthogonal features.Physical and engineering sciences in medicine · 2026Article
- Research Progress on the Effect of Exercise on Homocysteine.Current medicinal chemistry · 2026Review
- Treadmill exercise alleviates depression in female mice induced by chronic unpredictable mild stress through the Inhibition of cGAS-STING signalling.Scientific reports · 2025Article
- Running Reverses Chronic Stress-Induced Changes in Serotonergic Modulation of Hippocampal Granule Cells and Altered Behavioural Responses.The European journal of neuroscience · 2025Article
- A comprehensive review on the impact of polyphenol supplementation and exercise on depression and brain function parameters.Behavioral and brain functions : BBF · 2025Review
- Aerobic Exercise and Metformin: A Dual Approach to Enhancing Glycemic Maintenance in Type 2 Diabetes Mellitus.Chonnam medical journal · 2025Review
- Aerobic exercise improves depressive symptoms in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease.IBRO neuroscience reports · 2024Article
- Effect of high-intensity interval training on self-care and anxiety-like behaviors in naive rats.Experimental brain research · 2024Article
- Higher homocysteine and fibrinogen are associated with early-onset post-stroke depression in patients with acute ischemic stroke.Frontiers in psychiatry · 2024Article
- Psychological status and related factors of resident physicians during the release of COVID-19 pandemic restrictions in China.Frontiers in public health · 2024Article
- Acute hyper-hypoxia accelerates the development of depression in mice via the IL-6/PGC1α/MFN2 signaling pathway.Open medicine (Warsaw, Poland) · 2024Article
- Rehabilitation Training after Spinal Cord Injury Affects Brain Structure and Function: From Mechanisms to Methods.Biomedicines · 2023Review
- Lesion location and serum levels of homocysteine are associated with early-onset post-stroke depression in acute ischemic stroke.Brain and behavior · 2023Article
- Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats.International journal of molecular sciences · 2023Article
- Understanding target-specific effects of antidepressant drug pollution on molluscs: A systematic review protocol.PloS one · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
(1) Background: Depression is one of the overwhelming public health problems. Alleviating hippocampus injury may prevent depression development. Herein, we established the chronic unpredictable mild stress (CUMS) model and aimed to investigate whether aerobic exercise (AE) could alleviate CUMS induced depression-like behaviors and hippocampus injury. (2) Methods: Forty-eight healthy male Sprague-Dawley rats (200 ± 20 g) were randomly divided into 4 groups (control, CUMS, CUMS + 7 days AE, CUMS + 14 days AE). Rats with AE treatments were subjected to 45 min treadmill per day. (3) Results: AE intervention significantly improved CUMS-induced depressive behaviors, e.g., running square numbers and immobility time assessed by the open field and forced swimming test, suppressed hippocampal neuron apoptosis, reduced levels of phosphorylation of NMDA receptor and homocysteine in hippocampus, as well as serum glucocorticoids, compared to the CUMS rats. In contrast, AE upregulated phosphorylation of AMPAR receptor and brain-derived neurotrophic factor (BDNF) hippocampus in CUMS depression rats. The 14 day-AE treatment exhibited better performance than 7 day-AE on the improvement of the hippocampal function. (4) Conclusion: AE might be an efficient strategy for prevention of CUMS-induced depression via ameliorating hippocampus functions. Underlying mechanisms may be related with glutamatergic system, the neurotoxic effects of homocysteine, and/or influences in glucocorticoids-BDNF expression interaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.