ArticleBrain sciences2020
Cognitive Performance of Patients with Adult 5q-Spinal Muscular Atrophy and with Amyotrophic Lateral Sclerosis.
Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Cognitive and neurodevelopmental outcomes in spinal muscular atrophy: a scoping review.Frontiers in cellular neuroscience · 2026Review
- The role of cognitive and brain reserve in the clinical presentation and progression of amyotrophic lateral sclerosis.Scientific reports · 2025Article
- Exploring variability in cognitive functioning in patients with spinal muscular atrophy: a scoping review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Cognition and communication in patients with spinal muscular atrophy: A systematic review.Heliyon · 2024Article
- Cognitive impairment in children with 5q-associated spinal muscular atrophy type 1: two case reports and the review of the literature.Frontiers in pediatrics · 2024Article
- Cognitive performance of adult patients with SMA before and after treatment initiation with nusinersen.BMC neurology · 2023Article
- Patient Reported Outcome Measures in Adult Spinal Muscular Atrophy: A Scoping Review and Graphical Visualization of the Evidence.Journal of neuromuscular diseases · 2023Article
- Cognitive impairment in Chinese adult patients with type III spinal muscular atrophy without disease-modifying treatment.Frontiers in neurology · 2023Article
- Cognitive reserve protects ALS-typical cognitive domains: A longitudinal study.Annals of clinical and translational neurology · 2022Article
- Validity and reliability of the German multidimensional fatigue inventory in spinal muscular atrophy.Annals of clinical and translational neurology · 2022Article
- Loss of "insight" into behavioral changes in ALS: Differences across cognitive profiles.Brain and behavior · 2022Article
- Cognitive Impairment in Adult Patients with 5q-Associated Spinal Muscular Atrophy.Brain sciences · 2021Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor neuron diseases, such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS), share several clinical similarities while differing substantially in etiology, disease onset and progression. Cognitive dysfunction, a clinically relevant non-motor feature in a substantial proportion of ALS patients, has been less frequently investigated in SMA. In this prospective multicenter cross-sectional study, cognitive function was assessed by the Edinburgh Cognitive (and Behavioural) ALS Screen (ECAS) and a German vocabulary test (Wortschatztest, WST) in 34 adult patients with SMA types 2-4 and in 34 patients with ALS. Demographic and clinical parameters were assessed to identify factors that potentially influence cognitive function. While SMA and ALS patients were comparable in the vocabulary test, on average, SMA patients performed better than ALS patients in the cognitive domains of memory, language and executive function. Better cognitive abilities in SMA patients seemed to be related to the early onset, rather than the extent or the duration, of their physical handicap. Future studies should focus on disease-specific cognitive functions in SMA.
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