Evidence map›Paper›PMID 33374621›Full record

ArticleInternational journal of molecular sciences2020

The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the

Mirja Koch, Constanze Scheel, Hongwei Ma, Fan Yang, Michael Stadlmeier, Andrea F Glück, Elisa Murenu, Franziska R Traube, Thomas Carell, Martin Biel and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Integrative Kinase Activity Profiling and Phosphoproteomics ofInternational journal of molecular sciences · 2024
    Article
  3. cGMP Signaling in Photoreceptor Degeneration.International journal of molecular sciences · 2023
    Review
  4. Inherited Retinal Diseases.International journal of molecular sciences · 2022
    Article
  5. Achromatopsia: Genetics and Gene Therapy.Molecular diagnosis & therapy · 2022
    Review
  6. Human gene therapy · 2021
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Mirja KochDepartment of Pharmacy-Center for Drug Research, Ludwig-Maximilians-University, 81377 Munich, Germany.
Constanze ScheelDepartment of Pharmacy-Center for Drug Research, Ludwig-Maximilians-University, 81377 Munich, Germany.
Hongwei MaDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Fan YangDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Michael StadlmeierDepartment of Chemistry, Ludwig-Maximilians-University, 81377 Munich, Germany.ORCID 0000-0001-7806-3077
Andrea F GlückDepartment of Chemistry, Ludwig-Maximilians-University, 81377 Munich, Germany.
Elisa MurenuDepartment of Pharmacy-Center for Drug Research, Ludwig-Maximilians-University, 81377 Munich, Germany.
Franziska R TraubeDepartment of Chemistry, Ludwig-Maximilians-University, 81377 Munich, Germany.ORCID 0000-0002-5691-1941
Thomas CarellDepartment of Chemistry, Ludwig-Maximilians-University, 81377 Munich, Germany.
Martin BielDepartment of Pharmacy-Center for Drug Research, Ludwig-Maximilians-University, 81377 Munich, Germany.
Xi-Qin DingDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Stylianos MichalakisDepartment of Pharmacy-Center for Drug Research, Ludwig-Maximilians-University, 81377 Munich, Germany.ORCID 0000-0001-5092-9238
Ludwig-Maximilians-Universität München · DEUniversity of Oklahoma Health Sciences Center · US

Funding

P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan, MICHAEL H ELLIOTT · 2011 to 2026
$10.5M
Mechanism of Cone Degeneration Resulting from CNG Channel DeficiencyR01EY019490 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DING, XI-QIN · 2010 to 2014
$1.8M
The Role of Endoplasmic Reticulum Calcium Channels in Cone Degeneration Resulting from CNG Channel DeficiencyR01EY027754 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DING, XI-QIN · 2017 to 2020
$1.5M
NEI NIH HHS P30EY021725NEI NIH HHS R01 EY019490NEI NIH HHS R01 EY027754NEI NIH HHS R01EY027754
6 · The paper itself

Abstract

Mutations in the

Indexed as

AnimalsBiomarkersColor Vision DefectsCyclic GMPCyclic GMP-Dependent Protein Kinase Type IICyclic Nucleotide-Gated Cation ChannelsDisease Models, AnimalDisease SusceptibilityEndoplasmic Reticulum StressFluorescent Antibody TechniqueGene ExpressionMiceMice, KnockoutMicroscopy, ConfocalModels, BiologicalRetinal Cone Photoreceptor CellsBiomarkersCnga3 protein, mouseCyclic GMPCyclic GMP-Dependent Protein Kinase Type IICyclic Nucleotide-Gated Cation ChannelsachromatopsiacGMP cytotoxicitycone photoreceptorneuroprotectionphotoreceptor degeneration

Identifiers

PMID33374621
PMCPMC7793084
OpenAlexW3117398331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.