Evidence map›Paper›PMID 33374508›Full record

ReviewInternational journal of molecular sciences2020

The Aryl Hydrocarbon Receptor in Energy Balance: The Road from Dioxin-Induced Wasting Syndrome to Combating Obesity with Ahr Ligands.

Nathaniel G Girer, Craig R Tomlinson, Cornelis J Elferink

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. PMHeliyon · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
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  14. Article
  15. Special Issue on the "Regulation and Physiopathology of the Gut Barrier".International journal of molecular sciences · 2022
    Article
  16. Article
  17. Review
  18. DNA methylation profile of liver of mice conceived byJournal of developmental origins of health and disease · 2022
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nathaniel G GirerDepartment of Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX 77550, USA.
Craig R TomlinsonDepartment of Molecular and Systems Biology, Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Dartmouth College, Lebanon, NH 03756, USA.
Cornelis J ElferinkDepartment of Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX 77550, USA.ORCID 0000-0002-1281-7400
The University of Texas Medical Branch at Galveston · USDartmouth College · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Translational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2019 to 2026
$14.7M
Quantitative Biology Research InstituteP20GM103534 · NIGMS · DARTMOUTH COLLEGE · PI AMOS, CHRISTOPHER I. · 2012 to 2016
$8.6M
QUANTITATIVE BIOLOGY RESEARCH INSTITUTEP20RR024475 · NCRR · DARTMOUTH COLLEGE · PI MOORE, JASON H. · 2011 to 2011
$2.3M
Aryl Hydrocarbon Receptor-Mediated Epigenetic ProcessesR01ES026874 · NIEHS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ELFERINK, CORNELIS JOHAN · 2016 to 2020
$2.2M
Hepatic Aryl Hydrocarbon Receptor Regulation of Obesity: Mechanisms of ActionR01ES033682 · NIEHS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Casey W Wright · 2022 to 2026
$1.8M
Mechanistic Insights into Aryl Hydrocarbon Receptor Regulation of Fibroblast Growth Factor 21 and its Influence on Systemic Energy MetabolismF32DK116489 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GIRER, NATHANIEL · 2019 to 2019
$61k
NCI NIH HHS 5P30CA023108-41NCI NIH HHS P30 CA023108NCRR NIH HHS 5P20RR024475-02NIDDK NIH HHS F32DK116489NIEHS NIH HHS P30 ES030285NIEHS NIH HHS P30ES030285NIEHS NIH HHS R01 ES026874NIEHS NIH HHS R01ES026874NIEHS NIH HHS R01 ES033682NIGMS NIH HHS 8P20GM103534-02
6 · The paper itself

Abstract

The aryl hydrocarbon receptor (AHR) has been studied for over 40 years, yet our understanding of this ligand-activated transcription factor remains incomplete. Each year, novel findings continually force us to rethink the role of the AHR in mammalian biology. The AHR has historically been studied within the context of potent activation via AHR agonist 2,3,7,8-tetrachlorodibenzo-

Indexed as

Energy MetabolismAnimalsDioxinsDisease Models, AnimalDisease SusceptibilityDrug DevelopmentGene Expression RegulationHumansLigandsMice, TransgenicMolecular Targeted TherapyObesityPolychlorinated DibenzodioxinsReceptors, Aryl HydrocarbonWasting SyndromeDioxinsLigandsPolychlorinated DibenzodioxinsReceptors, Aryl Hydrocarbonaryl hydrocarbon receptorenergy metabolismobesity

Identifiers

PMID33374508
PMCPMC7793057
OpenAlexW3114680919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.