Evidence map›Paper›PMID 33374506›Full record

ReviewInternational journal of molecular sciences2020

Therapeutic Potential of Carbon Monoxide (CO) and Hydrogen Sulfide (H

Tamás Gáll, Dávid Pethő, Annamária Nagy, György Balla, József Balla

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tamás GállDivision of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Dávid PethőDivision of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Annamária NagyDivision of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
György BallaHAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, University of Debrecen, 4032 Debrecen, Hungary.
József BallaDivision of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
University of Debrecen · HU

Funding

European Union and the European Social Fund EFOP-3.6.2-16-2017-00006 (LIVE LONGER)European Union and the European Social Fund EFOP-3.6.3-VEKOP-16-2017-00009European Union and the European Social Fund GINOP-2.3.2-15-2016-00043 (IRONHEARTH)Hungarian Academy of Sciences 11003Hungarian Government grants OTKA-K112333 (J.B.)Thematic Excellence Programme of the Ministry for Innovation and Technology in Hungary within the framework of the Space Sciences thematic program of the University of Debrecen ED_18-1-2019-0028
6 · The paper itself

Abstract

Over the past decades, substantial work has established that hemoglobin oxidation and heme release play a pivotal role in hemolytic/hemorrhagic disorders. Recent reports have shown that oxidized hemoglobins, globin-derived peptides, and heme trigger diverse biological responses, such as toll-like receptor 4 activation with inflammatory response, reprogramming of cellular metabolism, differentiation, stress, and even death. Here, we discuss these cellular responses with particular focus on their mechanisms that are linked to the pathological consequences of hemorrhage and hemolysis. In recent years, endogenous gasotransmitters, such as carbon monoxide (CO) and hydrogen sulfide (H

Indexed as

AnimalsCarbon MonoxideDisease ManagementDisease SusceptibilityEnergy MetabolismHemeHeme Oxygenase-1Heme Oxygenase (Decyclizing)HemoglobinsHemolysisHumansHydrogen SulfideIgA VasculitisLipid MetabolismLipoproteins, LDLMonocytesCarbon MonoxideHemeHeme Oxygenase-1Heme Oxygenase (Decyclizing)HemoglobinsHydrogen SulfideLipoproteins, LDLoxidized low density lipoproteinPeptidesToll-Like Receptor 4carbon monoxidecarbon monoxide-releasing moleculeshemeheme oxygenasehemolysishemorrhagehydrogen sulfideoxidized hemoglobinvascular disease

Identifiers

PMID33374506
PMCPMC7793096
OpenAlexW3113944785

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.