Evidence map›Paper›PMID 33374188›Full record

ArticleMarine drugs2020

Flavonoid Glycosides with a Triazole Moiety for Marine Antifouling Applications: Synthesis and Biological Activity Evaluation.

Daniela Pereira, Catarina Gonçalves, Beatriz T Martins, Andreia Palmeira, Vitor Vasconcelos, Madalena Pinto, Joana R Almeida, Marta Correia-da-Silva, Honorina Cidade

Abstract read
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniela PereiraLaboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.ORCID 0000-0002-5711-7598
Catarina GonçalvesCIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
Beatriz T MartinsLaboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.
Andreia PalmeiraLaboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.ORCID 0000-0002-1391-2143
Vitor VasconcelosCIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.ORCID 0000-0003-3585-2417
Madalena PintoLaboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.ORCID 0000-0002-4676-1409
Joana R AlmeidaCIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.ORCID 0000-0001-9356-7265
Marta Correia-da-SilvaLaboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.ORCID 0000-0003-4150-8532
Honorina CidadeLaboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.ORCID 0000-0003-0715-1779

Funding

Fundação para a Ciência e a Tecnologia PTDC/AAG-TEC/0739/2014Fundação para a Ciência e a Tecnologia PTDC/BTA-BTA/31422/2017Fundação para a Ciência e a Tecnologia PTDC/SAU-PUB/28736/2017North Portugal Regional Operational Programme (Norte 2020) NORTE-01-0145-FEDER-000040
6 · The paper itself

Abstract

Over the last decades, antifouling coatings containing biocidal compounds as active ingredients were used to prevent biofouling, and eco-friendly alternatives are needed. Previous research from our group showed that polymethoxylated chalcones and glycosylated flavones obtained by synthesis displayed antifouling activity with low toxicity. In this work, ten new polymethoxylated flavones and chalcones were synthesized for the first time, including eight with a triazole moiety. Eight known flavones and chalcones were also synthesized and tested in order to construct a quantitative structure-activity relationship (QSAR) model for these compounds. Three different antifouling profiles were found: three compounds (

Indexed as

AnimalsArtemiaBiofilmsBiofoulingClick ChemistryFlavonoidsGlycosidesGreen Chemistry TechnologyHydrogen BondingMicroalgaeMolecular StructureMytilusQuantitative Structure-Activity RelationshipRoseobacterTriazolesWater MicrobiologyFlavonoidsGlycosidesTriazolesantifoulingbiofoulingclick chemistryeco-friendly alternativesflavonoidssynthesis

Identifiers

PMID33374188
PMCPMC7823860

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.