Evidence map›Paper›PMID 33374102›Full record

ArticleToxins2020

Shiga Toxin 2a Binds to Complement Components C3b and C5 and Upregulates Their Gene Expression in Human Cell Lines.

Sára Kellnerová, Sneha Chatterjee, Rafael Bayarri-Olmos, Louise Justesen, Heribert Talasz, Wilfried Posch, Samyr Kenno, Peter Garred, Dorothea Orth-Höller, Marco Grasse and 1 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Sára KellnerováInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstraβe 41, A-6020 Innsbruck, Austria.
Sneha ChatterjeeInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstraβe 41, A-6020 Innsbruck, Austria.
Rafael Bayarri-OlmosLaboratory of Molecular Medicine, Department of Clinical Immunology Section 7631, Rigshospitalet, University of Copenhagen, Ole Maaloesvej 26, 2200 Copenhagen, Denmark.ORCID 0000-0003-3202-9679
Louise JustesenLaboratory of Molecular Medicine, Department of Clinical Immunology Section 7631, Rigshospitalet, University of Copenhagen, Ole Maaloesvej 26, 2200 Copenhagen, Denmark.ORCID 0000-0001-9362-3837
Heribert TalaszCentre of Chemistry and Biomedicine, Division of Clinical Biochemistry, Medical University of Innsbruck, Innrain 80, A-6020 Innsbruck, Austria.
Wilfried PoschInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstraβe 41, A-6020 Innsbruck, Austria.ORCID 0000-0001-8955-7654
Samyr KennoInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstraβe 41, A-6020 Innsbruck, Austria.
Peter GarredLaboratory of Molecular Medicine, Department of Clinical Immunology Section 7631, Rigshospitalet, University of Copenhagen, Ole Maaloesvej 26, 2200 Copenhagen, Denmark.
Dorothea Orth-HöllerInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstraβe 41, A-6020 Innsbruck, Austria.
Marco GrasseInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstraβe 41, A-6020 Innsbruck, Austria.
Reinhard WürznerInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstraβe 41, A-6020 Innsbruck, Austria.ORCID 0000-0001-6804-442X
Innsbruck Medical University · ATUniversity of Copenhagen · DK

Funding

Austrian Science Fund FWF W 1253
6 · The paper itself

Abstract

Enterohemorrhagic

Indexed as

Cell LineCell SurvivalComplement C3bComplement C5Gene Expression RegulationHumansProtein BindingShiga ToxinUp-RegulationComplement C3bComplement C5Shiga ToxinShiga toxin subunit AC3C5HCT-8hemolytic uremic syndromeHK-2intracellular complementShiga toxin 2a

Identifiers

PMID33374102
PMCPMC7824702
OpenAlexW3117983764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.