Evidence map›Paper›PMID 33373851›Full record

ArticleThe Journal of surgical research2021

Mediators of Prolonged Hematopoietic Progenitor Cell Mobilization After Severe Trauma.

Getasha D Doobay, Elizabeth S Miller, Camille G Apple, Tyler J Loftus, Kolenkode B Kannan, Philip A Efron, Alicia M Mohr

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Getasha D DoobayCollege of Medicine, University of Florida, Gainesville, Florida.
Elizabeth S MillerDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida, Gainesville, Florida.
Camille G AppleDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida, Gainesville, Florida.
Tyler J LoftusDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida, Gainesville, Florida.
Kolenkode B KannanDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida, Gainesville, Florida.
Philip A EfronDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida, Gainesville, Florida.
Alicia M MohrDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida, Gainesville, Florida. Electronic address: alicia.mohr@surgery.ufl.edu.
University of Florida · US

Funding

PICS: A New Horizon for Surgical Critical CareP50GM111152 · NIGMS · UNIVERSITY OF FLORIDA · PI MOORE, FREDERICK A · 2014 to 2018
$10.7M
Molecular Biology in Burns and TraumaT32GM008721 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron · 1999 to 2026
$5.0M
Chronic Stress and Anemia Recovery following Major TraumaR01GM105893 · NIGMS · UNIVERSITY OF FLORIDA · PI MOHR, ALICIA M · 2013 to 2021
$3.5M
STUDENTS IN HEALTH PROFESSIONAL SCHOOLST35HL007489 · NHLBI · UNIVERSITY OF FLORIDA · PI Scott A Berceli, Robert Maile · 1985 to 2026
$2.4M
Hematopoietic Stem Cell Dysfunction in the Elderly after Severe InjuryR01GM113945 · NIGMS · UNIVERSITY OF FLORIDA · PI EFRON, PHILIP A · 2015 to 2019
$1.6M
NHLBI NIH HHS T35 HL007489NIGMS NIH HHS P50 GM111152NIGMS NIH HHS R01 GM105893NIGMS NIH HHS R01 GM113945NIGMS NIH HHS T32 GM008721
6 · The paper itself

Abstract

backgroundThis study investigated the molecular mediators of prolonged hematopoietic progenitor cell mobilization a trauma and chronic stress and the role of propranolol in modifying this response.

methodsSprague-Dawley rats were randomized to lung contusion (LC), LC plus hemorrhagic shock (LCHS), or LCHS with daily restraint stress (LCHS/CS). Propranolol was administered daily. Bone marrow (BM) and lung expression of high mobility group box 1 (HMGB1), granulocyte colony-stimulating factor (G-CSF), neutrophil elastase, stromal cell-derived factor 1 (SDF-1)/CXR4, and vascular cell adhesion protein 1 (VCAM-1)/very late antigen-4 were measured by real-time polymerase chain reaction.

resultsBone marrow HMGB1, G-CSF, and neutrophil elastase expression were significantly elevated two- to four-fold after LCHS/CS, and all were decreased with the use of propranolol. SDF-1 and VCAM-1 were both significantly decreased after LCHS/CS.

conclusionsThe increased expression of HMGB1 and G-CSF and decreased expression of BM anchoring molecules, SDF-1 and VCAM-1, after LCHS/CS, likely mediates prolonged hematopoietic progenitor cell mobilization. Propranolol's ability to reduce HMGB1, G-CSF, and neutrophil elastase expression suggests that the mobilization of hematopoietic progenitor cells was driven by persistent hypercatecholaminemia.

Indexed as

Adrenergic beta-AntagonistsAnimalsBiomarkersBone MarrowChronic DiseaseContusionsEnzyme-Linked Immunosorbent AssayHematopoietic Stem CellsLung InjuryMalePropranololRandom AllocationRatsRats, Sprague-DawleyReal-Time Polymerase Chain ReactionRestraint, PhysicalAdrenergic beta-AntagonistsBiomarkersPropranololG-CSFHematopoietic progenitor cell mobilizationHMGB1Neutrophil elastaseTraumaVCAM-1

Identifiers

PMID33373851
PMCPMC8025599
OpenAlexW3116444649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.