Evidence map›Paper›PMID 33373777›Full record

ArticleJournal of psychiatric research2021

Glucocorticoid regulation and neuroanatomy in fragile x syndrome.

Jennifer L Bruno, David S Hong, Amy A Lightbody, S M Hadi Hosseini, Joachim Hallmayer, Allan L Reiss

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jennifer L BrunoDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94304, USA. Electronic address: bruno.jennifer@gmail.com.
David S HongDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94304, USA.
Amy A LightbodyDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94304, USA.
S M Hadi HosseiniDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94304, USA.
Joachim HallmayerDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94304, USA.
Allan L ReissDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94304, USA; Department of Radiology, Stanford University, Stanford, CA, 94304, USA; Department of Pediatrics, Stanford University, Stanford, CA, 94304, USA. Electronic address: areiss1@stanford.edu.
Stanford University · US

Funding

NEUROPSYCHIATRIC-MOLECULAR ASSOCIATIONS IN FRAGILE X SYNR01MH050047 · NIMH · STANFORD UNIVERSITY · PI REISS, ALLAN L · 1993 to 2022
$12.5M
TRAINING FOR CHILD PSYCHIATRY AND CHILD DEVELOPMENTT32MH019908 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB, DAVID S HONG · 1993 to 2026
$6.3M
A Novel Neuromonitoring Guided Cognitive Intervention for Targeted Enhancement of Working MemoryR61MH119289 · NIMH · STANFORD UNIVERSITY · PI HOSSEINI, HADI · 2019 to 2021
$787k
The influence of multi-domain cognitive training on large-scale structural and functional brain networks in MCIK25AG050759 · NIA · STANFORD UNIVERSITY · PI HOSSEINI, HADI · 2016 to 2020
$739k
Neuroanatomical substrates of cognition in mosaic Turner syndromeK23MH097120 · NIMH · STANFORD UNIVERSITY · PI HONG, DAVID S · 2012 to 2015
$725k
NIA NIH HHS K25 AG050759NIMH NIH HHS K23 MH097120NIMH NIH HHS R01 MH050047NIMH NIH HHS R61 MH119289NIMH NIH HHS T32 MH019908
6 · The paper itself

Abstract

Fragile X syndrome (FXS) is the leading known inherited cause for intellectual disability. Due to mutations in the FMR1 gene, affected individuals are at risk for serious cognitive and behavioral symptoms and developmental disability. Clinical presentation varies considerably, and investigation of genetic factors not directly related to FMR1 may help better understand variability. The present study examined the BclI polymorphism of the glucocorticoid receptor gene NR3C1 in 43 individuals with FXS (28 females, age 16 to 25). Females with FXS who presented with one or more G alleles demonstrated attenuated symptoms of anxiety/depression (p = 0.038) and externalizing behaviors (p = 0.042) relative to individuals with the C/C allele. In the combined sample (males and females) structural neuroimaging data differentiated individuals with a G allele from those with the C/C genotype (p < 0.001). Key components of anxiety/fear neurocircuitry (amygdala, insula) contributed more (relative to other regions) to the model differentiating groups. These results indicate that GR polymorphisms are associated with an altered pattern of behavioral and brain development in FXS. This information is important for understanding and treating mood disorders and altered brain development among individuals with FXS. With further research, these findings could be informative for understanding anxiety and mood disorders more broadly.

Indexed as

Fragile X SyndromeGlucocorticoidsAdolescentAdultAllelesFemaleFragile X Messenger Ribonucleoprotein 1HumansMaleNeuroanatomyYoung AdultFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1GlucocorticoidsAnxietyBclI polymorphismFMR1Multivariate pattern classificationStructural MRI

Identifiers

PMID33373777
PMCPMC8577316
OpenAlexW3112489075

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.