Evidence map›Paper›PMID 33373700›Full record

ReviewCurrent opinion in insect science2021

Short term transcriptional responses of P450s to phytochemicals in insects and mites.

Marilou Vandenhole, Wannes Dermauw, Thomas Van Leeuwen

Open access · hybridAbstract readReview
In one paragraph

Review in Current opinion in insect science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Insects · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Marilou VandenholeLaboratory of Agrozoology, Department of Plants and Crops, Faculty of Bioscience Engineering, Coupure Iinks 653, 9000 Ghent, Belgium.
Wannes DermauwLaboratory of Agrozoology, Department of Plants and Crops, Faculty of Bioscience Engineering, Coupure Iinks 653, 9000 Ghent, Belgium.
Thomas Van LeeuwenLaboratory of Agrozoology, Department of Plants and Crops, Faculty of Bioscience Engineering, Coupure Iinks 653, 9000 Ghent, Belgium. Electronic address: thomas.vanleeuwen@ugent.be.
Ghent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytochrome P450 monooxygenases (P450s) play a key role in the detoxification of phytochemicals in arthropod herbivores. We present here an overview of recent progress in understanding the breadth and specificity of gene expression plasticity of P450s in response to phytochemicals. We discuss experimental setups and new findings in mechanisms of P450 regulation. Whole genome transcriptomic analysis of arthropod herbivores, either after direct administration of phytochemicals or after host plant shifts, allowed to integrate various levels of chemical complexity and lead to the unbiased identification of responsive P450 genes. However, despite progress in identification of inducible P450s, the link between induction and metabolism is still largely unexplored, and to what extent the overall response is biologically functional should be further investigated. In the near future, such studies will be more straightforward as forward and reverse genetic tools become more readily available.

Indexed as

AnimalsCytochrome P-450 Enzyme SystemInsectaMitesPhytochemicalsPlant Defense Against HerbivoryTranscriptomeCytochrome P-450 Enzyme SystemPhytochemicals

Identifiers

PMID33373700
PMCPMC8082277
OpenAlexW3115969791

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.