Evidence map›Paper›PMID 33373663›Full record

ArticleToxicology letters2021

Exposure to traffic-generated air pollution promotes alterations in the integrity of the brain microvasculature and inflammation in female ApoE

Anna Adivi, JoAnn Lucero, Nicholas Simpson, Jacob D McDonald, Amie K Lund

Abstract read
In one paragraph

Article in Toxicology letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna AdiviAdvanced Environmental Research Institute, Department of Biological Sciences, University of North Texas, Denton, TX, 76201, USA.
JoAnn LuceroAdvanced Environmental Research Institute, Department of Biological Sciences, University of North Texas, Denton, TX, 76201, USA.
Nicholas SimpsonLovelace Biomedical and Environmental Research Institute, Albuquerque, NM, 87108, USA.
Jacob D McDonaldLovelace Biomedical and Environmental Research Institute, Albuquerque, NM, 87108, USA.
Amie K LundAdvanced Environmental Research Institute, Department of Biological Sciences, University of North Texas, Denton, TX, 76201, USA. Electronic address: amie.lund@unt.edu.

Funding

The Renin-Angiotensin System in Air Pollution-Mediated Exacerbation of Obesity.R15ES026795 · NIEHS · UNIVERSITY OF NORTH TEXAS · PI LUND, AMIE KATHLEEN · 2017 to 2023
$874k
MMP-9 Activity Mediates Vascular Effects of Inhaled Environmental Air PollutantsR00ES016586 · NIEHS · LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE · PI LUND, AMIE KATHLEEN · 2009 to 2011
$761k
NIEHS NIH HHS R00 ES016586NIEHS NIH HHS R15 ES026795
6 · The paper itself

Abstract

Traffic-generated air pollutants have been correlated with alterations in blood-brain barrier (BBB) integrity, which is associated with pathologies in the central nervous system (CNS). Much of the existing literature investigating the effects of air pollution in the CNS has predominately been reported in males, with little known regarding the effects in females. As such, this study characterized the effects of inhalation exposure to mixed vehicle emissions (MVE), as well as the presence of female sex hormones, in the CNS of female ApoE

Indexed as

Air PollutantsAnimalsApolipoproteins EBrainCentral Nervous SystemFemaleHumansInflammationMiceMicrovesselsModels, AnimalPeptide FragmentsVehicle EmissionsAir PollutantsApolipoproteins EPeptide FragmentsVehicle EmissionsAir pollutionBBB integrityBrainFemaleInflammatory markers

Identifiers

PMID33373663
PMCPMC7864563

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.