Evidence map›Paper›PMID 33373474›Full record

ArticleNeurogastroenterology and motility2021

Novel gel bolus to improve impedance-based measurements of esophageal cross-sectional area during primary peristalsis.

Melissa Ledgerwood, Ali Zifan, William Lin, Jesse de Alva, Haojin Chen, Ravinder K Mittal

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06665971 (Effect of Dupilumab on Esophageal Peristaltic Function in Participants with Eosinophilic Esophagitis), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06665971 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Dupilumab on Esophageal Peristaltic Function in Participants with Eosinophilic Esophagitis

TypeinterventionalSponsorUniversity of California, San DiegoRan2024 to 2026Enrolled30ConditionsEosinophilic Esophagitis (EoE)ArmsDupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Melissa LedgerwoodDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-3705-3889
Ali ZifanDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
William LinDivision of Biology, University of California San Diego, La Jolla, CA, USA.
Jesse de AlvaDepartment of Electrical & Computer Engineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA.
Haojin ChenDepartment of Mechanical and Aerospace Engineering, Jacobs School of Engineering, University of California, La Jolla, CA, USA.
Ravinder K MittalDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-5228-9617
University of California San Diego · USUniversity of California System · US

Funding

Novel Electrical Impedance Methodology to Understand Functional DysphagiaR01DK109376 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MITTAL, RAVINDER K. · 2016 to 2020
$2.5M
NIDDK NIH HHS R01 DK109376NIH HHS R01 DK109376
6 · The paper itself

Abstract

introductionIntraluminal esophageal impedance (ILEE) has the potential to measure esophageal luminal distension during swallow-induced peristalsis in the esophagus. A potential cause of inaccuracy in the ILEE measurement is the swallow-induced air in the bolus.

aimCompare a novel gel bolus to the current alternatives for the measurement of impedance-based luminal distension (cross-sectional area, CSA) during primary peristalsis.

methods12 healthy subjects were studied using high-resolution impedance manometry (HRMZ) and concurrently performed intraluminal ultrasound (US) imaging of the esophagus. Three test bolus materials were used: 1) novel gel, 2) 0.5 N saline, and 3) commercially available Diversatek EFTV viscous. Testing was performed in the supine and Trendelenburg (-15°) positions. US imaging assessed air in the bolus and luminal CSA. The Nadir impedance values were correlated to the US measured CSA. A custom Matlab software was used to assess the bolus travel times and impedance-based luminal CSA.

resultsThe novel gel bolus had the least amount of air in the bolus during its passage through the esophagus, as assessed by US image analysis. The novel gel bolus in the supine and Trendelenburg positions had the best linear fit between the US measured CSA and nadir impedance value (R

conclusionWe suggest the use of novel gel to assess distension along with contraction during routine clinical HRM testing.

Indexed as

GelsAdultAgedEsophagusFemaleHumansMaleManometryMiddle AgedPeristalsisPlethysmography, ImpedanceUltrasonographyGelsesophageal distensionesophageal impedanceintraluminal esophageal impedanceprimary peristalsisswallow gel

Identifiers

PMID33373474
PMCPMC13431245
OpenAlexW3115940838

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.