Evidence map›Paper›PMID 33373391›Full record

ArticlePloS one2020

Closed-loop control of k-space sampling via physiologic feedback for cine MRI.

Francisco Contijoch, Yuchi Han, Srikant Kamesh Iyer, Peter Kellman, Gene Gualtieri, Mark A Elliott, Sebastian Berisha, Joseph H Gorman, Robert C Gorman, James J Pilla and 1 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Francisco ContijochDepartment of Bioengineering, Jacobs School of Engineering, University of California, San Diego, CA, United States of America.ORCID 0000-0001-9616-3274
Yuchi HanDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Srikant Kamesh IyerDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Peter KellmanNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America.
Gene GualtieriAJO, Philadelphia, PA, United States of America.
Mark A ElliottDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Sebastian BerishaDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Joseph H GormanDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Robert C GormanDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
James J PillaDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Walter R T WitscheyDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
University of Pennsylvania · USNational Institutes of Health · USUniversity of California San Diego · US

Funding

Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
Surgery to Prevent Post Infarction Ventricular RemodelingR01HL063954 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GORMAN, ROBERT C · 2001 to 2018
$9.8M
UCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3M
Imaging-based Indentification of Premature Ventricular Contraction-mediatedR01HL148103 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HAN, YUCHI · 2020 to 2025
$2.8M
Cardiac MR imaging of hemorrhagic reperfusion injury after myocardial infarctionR01HL137984 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WITSCHEY, WALTER R.T. · 2018 to 2022
$2.8M
Nuclear Magnetic Tirho Relaxation in Acute and Chronic Myocardial InfarctionsR00HL108157 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WITSCHEY, WALTER R.T. · 2014 to 2016
$747k
Replacement of Small Animal Echocardiographic InstrumentationS10OD010417 · OD · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI ROSS, ROBERT SCOTT · 2012 to 2012
$371k
Nuclear magnetic Tirho relaxation in acute and chronic myocardial infarctionsK99HL108157 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WITSCHEY, WALTER R.T. · 2012 to 2013
$160k
Use of Real Time MRI for Evaluation of Regional Myocardial FunctionF31HL120580 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CONTIJOCH, FRANCISCO J · 2014 to 2015
$49k
NHLBI NIH HHS F31 HL120580NHLBI NIH HHS K99 HL108157NHLBI NIH HHS R00 HL108157NHLBI NIH HHS R01 HL063954NHLBI NIH HHS R01 HL137984NHLBI NIH HHS R01 HL148103NHLBI NIH HHS R25 HL145817NHLBI NIH HHS T32 HL007444NIH HHS S10 OD010417
6 · The paper itself

Abstract

backgroundSegmented cine cardiac MRI combines data from multiple heartbeats to achieve high spatiotemporal resolution cardiac images, yet predefined k-space segmentation trajectories can lead to suboptimal k-space sampling. In this work, we developed and evaluated an autonomous and closed-loop control system for radial k-space sampling (ARKS) to increase sampling uniformity.

methodsThe closed-loop system autonomously selects radial k-space sampling trajectory during live segmented cine MRI and attempts to optimize angular sampling uniformity by selecting views in regions of k-space that were not previously well-sampled. Sampling uniformity and the ability to detect cardiac phase in vivo was assessed using ECG data acquired from 10 normal subjects in an MRI scanner. The approach was then implemented with a fast gradient echo sequence on a whole-body clinical MRI scanner and imaging was performed in 4 healthy volunteers. The closed-loop k-space trajectory was compared to random, uniformly distributed and golden angle view trajectories via measurement of k-space uniformity and the point spread function. Lastly, an arrhythmic dataset was used to evaluate a potential application of the approach.

resultsThe autonomous trajectory increased k-space sampling uniformity by 15±7%, main lobe point spread function (PSF) signal intensity by 6±4%, and reduced ringing relative to golden angle sampling. When implemented, the autonomous pulse sequence prescribed radial view angles faster than the scan TR (0.98 ± 0.01 ms, maximum = 1.38 ms) and increased k-space sampling mean uniformity by 10±11%, decreased uniformity variability by 44±12%, and increased PSF signal ratio by 6±6% relative to golden angle sampling.

conclusionThe closed-loop approach enables near-uniform radial sampling in a segmented acquisition approach which was higher than predetermined golden-angle radial sampling. This can be utilized to increase the sampling or decrease the temporal footprint of an acquisition and the closed-loop framework has the potential to be applied to patients with complex heart rhythms.

Indexed as

AdultAlgorithmsFemaleHealthy VolunteersHeartHumansImage EnhancementImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMale

Identifiers

PMID33373391
PMCPMC7771662
OpenAlexW3117990982

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.