Evidence map›Paper›PMID 33373366›Full record

ArticlePloS one2020

Excessive premature mortality among children with cerebral palsy in rural Uganda: A longitudinal, population-based study.

Lukia H Namaganda, Rita Almeida, Dan Kajungu, Fred Wabwire-Mangen, Stefan Peterson, Carin Andrews, Ann Christin Eliasson, Angelina Kakooza-Mwesige, Hans Forssberg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Lukia H NamagandaMakerere University School of Public Health, Makerere University, Kampala, Uganda.
Rita AlmeidaStockholm University Brain Imaging Center (SUBIC), Stockholm University, Stockholm, Sweden.
Dan KajunguIganga Mayuge Health and Demographic Surveillance Site (IMHDSS), Makerere University Centre for Health and Population Research (MUCHAP), Makerere University, Kampala, Uganda.
Fred Wabwire-MangenDepartment of Epidemiology and Biostatistics, Makerere University School of Public Health, Makerere University, Kampala, Uganda.
Stefan PetersonDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Carin AndrewsDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Ann Christin EliassonDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Angelina Kakooza-MwesigeDepartment of Pediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda.
Hans ForssbergDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-2069-6618
Makerere University · UGKarolinska Institutet · SEStockholm University · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies from high-income countries reported reduced life expectancy in children with cerebral palsy (CP), while no population-based study has evaluated mortality of children with CP in sub-Saharan Africa. This study aimed to estimate the mortality rate (MR) of children with CP in a rural region of Uganda and identify risk factors and causes of death (CODs). METHODS AND

findingsThis population-based, longitudinal cohort study was based on data from Iganga-Mayuge Health and Demographic Surveillance System in eastern Uganda. We identified 97 children (aged 2-17 years) with CP in 2015, whom we followed to 2019. They were compared with an age-matched cohort from the general population (n = 41 319). MRs, MR ratios (MRRs), hazard ratios (HRs), and immediate CODs were determined. MR was 3952 per 100 000 person years (95% CI 2212-6519) in children with CP and 137 per 100 000 person years (95% CI 117-159) in the general population. Standardized MRR was 25·3 in the CP cohort, compared with the general population. In children with CP, risk of death was higher in those with severe gross motor impairments than in those with milder impairments (HR 6·8; p = 0·007) and in those with severe malnutrition than in those less malnourished (HR = 3·7; p = 0·052). MR was higher in females in the CP cohort, with a higher MRR in females (53·0; 95% CI 26·4-106·3) than in males (16·3; 95% CI 7·2-37·2). Age had no significant effect on MR in the CP cohort, but MRR was higher at 10-18 years (39·6; 95% CI 14·2-110·0) than at 2-6 years (21·0; 95% CI 10·2-43·2). Anaemia, malaria, and other infections were the most common CODs in the CP cohort.

conclusionsRisk of premature death was excessively high in children with CP in rural sub-Saharan Africa, especially in those with severe motor impairments or malnutrition. While global childhood mortality has significantly decreased during recent decades, this observed excessive mortality is a hidden humanitarian crisis that needs to be addressed.

Indexed as

Mortality, PrematureAdolescentCerebral PalsyChildChild, PreschoolCohort StudiesFemaleHumansInfantLongitudinal StudiesMaleRisk FactorsRural PopulationUganda

Identifiers

PMID33373366
PMCPMC7771855
OpenAlexW3114010285

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.