ArticleAging2020
Time gap between the onset and diagnosis in Werner syndrome: a nationwide survey and the 2020 registry in Japan.
Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial.Aging cell · 2025Trial
- Comparison of Metabolic Dysfunction-Associated Steatotic Liver Disease Between Individuals With Werner Syndrome and Those With Insulin-Resistant Type 2 Diabetes: Hepatic Steatosis and Fibrosis Indices.Geriatrics & gerontology international · 2026Article
- Ocular Manifestations in Patients with Werner Syndrome.International journal of molecular sciences · 2026Review
- For early diagnosis of young patients with Werner syndrome: Indication for genetic testing.Geriatrics & gerontology international · 2025Article
- Article
- Surgical treatment of lung cancer associated with Werner's syndrome: A case report and review of the literature.Respirology case reports · 2024Article
- The identification of a novel mutation (p.I223fs) in WRN associated with Werner syndrome.Endocrine · 2024Article
- Sex differences in symptom presentation and their impact on diagnostic accuracy in Werner syndrome.Geriatrics & gerontology international · 2024Article
- Senescence-associated inflammation and inhibition of adipogenesis in subcutaneous fat in Werner syndrome.Aging · 2023Article
- Article
- Optical coherence tomography findings in three patients with Werner syndrome.BMC ophthalmology · 2022Article
- Lifetime extension and the recent cause of death in Werner syndrome: a retrospective study from 2011 to 2020.Orphanet journal of rare diseases · 2022Article
- Targeted long-read sequencing identifies missing pathogenic variants in unsolved Werner syndrome cases.Journal of medical genetics · 2022Article
- Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes.Journal of atherosclerosis and thrombosis · 2022Review
- Werner syndrome presenting as early-onset diabetes: A case report.Journal of diabetes investigation · 2022Article
- Case Report: A novelFrontiers in endocrinology · 2022Article
- Differences of Sleep Disorders Between Vestibular Migraine and Benign Paroxysmal Positional Vertigo.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
24 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with Werner syndrome present with diverse signs of aging that begin in adolescence. A Japanese nationwide survey was conducted to establish a registry that could clarify the disease profile of patients with Werner syndrome. The questionnaires were sent to 7888 doctors. The survey identified 116 patients diagnosed with Werner syndrome based on the diagnosis criteria. Forty patients were enrolled in the registry. Data on clinical symptoms, treatment information, and laboratory examination from patients who provided informed consent were collected. The data at enrollment were analyzed. The patients' average age at enrollment was 50.1±7.5 years. The mean onset age was 26.1±9.5 years, but the mean age at diagnosis was 42.5±8.6 years. Average height and weight of the study patients were lower than those of Japanese individuals. Almost all patients experienced hair change and cataracts. More than 60% of patients presented with glycolipid abnormalities. Overall, 15% of patients had a history of foot amputation. Approximately 30% of the patients' parents had a consanguineous marriage. The average grip strength, walking speed, and skeletal muscle mass index met the diagnostic criteria for sarcopenia. The registry revealed that there are opportunities for early diagnosis and intervention; therefore, sensitization about the disease is needed.
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