Evidence map›Paper›PMID 33373198›Full record

ArticleChemical research in toxicology2021

Biological Distribution and Metabolic Profiles of Carbon-11 and Fluorine-18 Tracers of VX- and Sarin-Analogs in Sprague-Dawley Rats.

Thomas R Hayes, Chih-Kai Chao, Joseph E Blecha, Tony L Huynh, Kurt R Zinn, Charles M Thompson, John M Gerdes, Henry F VanBrocklin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. [The Journal of pharmacology and experimental therapeutics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Thomas R HayesDepartment of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California 94143, United States.
Chih-Kai ChaoDepartment of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812, United States.ORCID 0000-0001-7984-2849
Joseph E BlechaDepartment of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California 94143, United States.
Tony L HuynhDepartment of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California 94143, United States.
Kurt R ZinnDepartments of Radiology, Small Animal Clinical Sciences, and Biomedical Engineering; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan 48824, United States.
Charles M ThompsonDepartment of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812, United States.
John M GerdesDepartment of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812, United States.ORCID 0000-0002-2768-5754
Henry F VanBrocklinDepartment of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California 94143, United States.ORCID 0000-0003-2849-0841
University of California, San Francisco · USUniversity of Montana · USMichigan State University · US

Funding

Molecular Imaging of Chemical Threats and CountermeasuresU01NS092495 · NINDS · UNIVERSITY OF MONTANA · PI GERDES, JOHN M, THOMPSON, CHARLES MARK · 2015 to 2019
$3.9M
NINDS NIH HHS U01 NS092495
6 · The paper itself

Abstract

Organophosphorus esters (OPs) were originally developed as pesticides but were repurposed as easily manufactured, inexpensive, and highly toxic chemical warfare agents. Acute OP toxicity is primarily due to inhibition of acetylcholinesterase (AChE), an enzyme in the central and peripheral nervous system. OP inhibition of AChE can be reversed using oxime reactivators but many show poor CNS penetration, indicating a need for new clinically viable reactivators. However, challenges exist on how to best measure restored AChE activity in vivo and assess the reactivating agent efficacy. This work reports the development of molecular imaging tools using radiolabeled OP analog tracers that are less toxic to handle in the laboratory, yet inhibit AChE in a similar fashion to the actual OPs. Carbon-11 and fluorine-18 radiolabeled analog tracers of VX and sarin OP agents were prepared. Following intravenous injection in normal Sprague-Dawley rats (

Indexed as

AcetylcholinesteraseAnimalsCarbon RadioisotopesChemical Warfare AgentsCholinesterase InhibitorsFluorine RadioisotopesMaleMolecular StructureOrganothiophosphorus CompoundsRatsRats, Sprague-DawleySarinTissue DistributionAcetylcholinesteraseCarbon-11Carbon RadioisotopesChemical Warfare AgentsCholinesterase InhibitorsFluorine-18Fluorine RadioisotopesOrganothiophosphorus CompoundsSarinVX-agent

Identifiers

PMID33373198
PMCPMC7818893
OpenAlexW3114566132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.