ReviewPediatric cardiology2021
Antenatal and Perioperative Mechanisms of Global Neurological Injury in Congenital Heart Disease.
Review in Pediatric cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Bilateral Transcranial Doppler Monitoring During Neonatal Cardiac Surgery; Guidance for Clinical and Scientific Use.Paediatric anaesthesia · 2026Article
- Clinical research study: cerebral autoregulation in neonates and infants undergoing open heart surgery: global patterns and derived cerebral hemodynamic metrics.Pediatric research · 2026Observational
- Perioperative Factors Associated with 2-Year Neurodevelopmental Outcome in Neonates Undergoing Congenital Cardiac Surgery with Cardiopulmonary Bypass: A Single-Center Cohort Study.Pediatric cardiology · 2026Article
- Postoperative S100B protein levels as a measure for predicting neurological deficit in children undergoing cardiac surgery.Frontiers in cardiovascular medicine · 2026Article
- Neurodevelopment in congenital heart disease: a review of antenatal mechanisms and therapeutic potentials.Pediatric research · 2025Review
- Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography.Developmental medicine and child neurology · 2025Review
- Fetal brain injury in the pump twin of a TRAP sequence with favorable postnatal outcome: a case report.BMC pregnancy and childbirth · 2025Article
- Selective antegrade cerebral perfusion: Still favored?JTCVS open · 2025Article
- Non-invasive monitoring of cerebral blood flow during cardiac surgery for congenital heart disease - transfontanellar Doppler as additional tool.Pediatric research · 2025Article
- Cerebral and Splanchnic Tissue Oxygenation Are Significantly Affected in Premature infants with Ductal-Dependent Congenital Heart Disease.Journal of pediatrics. Clinical practice · 2024Article
- [Research progress on neurodevelopmental disorders associated with congenital heart disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Recent Advances in Hydrogel-Based 3D Bioprinting and Its Potential Application in the Treatment of Congenital Heart Disease.Biomolecules · 2024Review
- Article
- Continuous Data-Driven Monitoring in Critical Congenital Heart Disease: Clinical Deterioration Model Development.JMIR cardio · 2023Article
- SOX7 loss-of-function variation as a cause of familial congenital heart disease.American journal of translational research · 2022Article
- Therapeutic hypothermia for encephalopathic newborns with congenital heart defect: A cross-sectional survey on current practices and opinions in Germany.Frontiers in pediatrics · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital heart defects (CHD) is one of the most common types of birth defects. Thanks to advances in surgical techniques and intensive care, the majority of children with severe forms of CHD survive into adulthood. However, this increase in survival comes with a cost. CHD survivors have neurological functioning at the bottom of the normal range. A large spectrum of central nervous system dysmaturation leads to the deficits seen in critical CHD. The heart develops early during gestation, and CHD has a profound effect on fetal brain development for the remainder of gestation. Term infants with critical CHD are born with an immature brain, which is highly susceptible to hypoxic-ischemic injuries. Perioperative blood flow disturbances due to the CHD and the use of cardiopulmonary bypass or circulatory arrest during surgery cause additional neurological injuries. Innate patient factors, such as genetic syndromes and preterm birth, and postoperative complications play a larger role in neurological injury than perioperative factors. Strategies to reduce the disability burden in critical CHD survivors are urgently needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.