ArticleInvestigative ophthalmology & visual science2020
Focal Structure-Function Relationships in Primary Open-Angle Glaucoma Using OCT and OCT-A Measurements.
Article in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Explainable Multimodal OCT and OCTA Analysis Reveals Structural and Vascular Features of Mild Glaucoma Across Ethnicities.Investigative ophthalmology & visual science · 2026Observational
- Reproducibility of VF, OCT, and OCTA in Glaucoma: A Prospective Multi-Visit Study.Translational vision science & technology · 2026Article
- Peripapillary Retinal and Choroidal Vasculature in Patients with Diabetes of Different Durations without Clinical Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Relationship Between Macular Perfusion Density and Central Visual Field Loss in Primary Open Angle Glaucoma.Journal of glaucoma · 2026Article
- Current Status and Future Perspectives of Optic Nerve Imaging in Glaucoma.Journal of clinical medicine · 2024Review
- Recently Approved Drugs for Lowering and Controlling Intraocular Pressure to Reduce Vision Loss in Ocular Hypertensive and Glaucoma Patients.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Combining Optical Coherence Tomography and Optical Coherence Tomography Angiography Longitudinal Data for the Detection of Visual Field Progression in Glaucoma.American journal of ophthalmology · 2023Article
- Retinal Oxygen Extraction in Patients with Primary Open-Angle Glaucoma.International journal of molecular sciences · 2022Article
- Comparison of machine learning approaches for structure-function modeling in glaucoma.Annals of the New York Academy of Sciences · 2022Article
- Multilayer Macula Vessel Density and Visual Field Progression in Glaucoma.American journal of ophthalmology · 2022Article
- Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss.Annals of the New York Academy of Sciences · 2022Article
- A Global and Sector-Based Comparison of OCT Angiography and Visual Field Defects in Glaucoma.Journal of ophthalmology · 2022Article
- Combining OCT and OCTA for Focal Structure-Function Modeling in Early Primary Open-Angle Glaucoma.Investigative ophthalmology & visual science · 2021Article
- Multipressure Dial Goggle Effects on Circumpapillary Structure and Microvasculature in Glaucoma Patients.Ophthalmology. GlaucomaArticle
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate the focal structure-function associations among visual field (VF) loss, optical coherence tomography angiography (OCT-A) vascular measurements, and optical coherence tomography (OCT) structural measurements in glaucoma. Methods: In this cross-sectional study, subjects underwent standard automated perimetry, OCT-based nerve fiber thickness measurements, and OCT-A imaging. Mappings of focal VF test locations with OCT and OCT-A measurements were defined using anatomically adjusted nerve fiber trajectories and were studied using multivariate mixed-effects analysis. Segmented regression analysis was used to determine the presence of breakpoints in the structure-function associations. Results: The study included 119 eyes from 86 Chinese subjects with primary open-angle glaucoma (POAG). VF mean deviation was significantly associated with global capillary perfusion density (β = 0.13 ± 0.08) and global retinal nerve fiber layer thickness (β = 0.09 ± 0.02). Focal capillary density (FCD) was significantly associated with VF losses at 34 VF test locations (66.7% of 24-2 VF), with 24 of the 34 locations being within 20° of retinal eccentricity. Focal nerve layer (FNL) thickness was significantly associated with 16 VF test locations (31.4% of 24-2 VF; eight locations within 20° eccentricity). For VF test locations in the central 10° VF, VF losses below the breakpoint were significantly associated with FCD (slope, 0.89 ± 0.12, P < 0.001), but not with FNL thickness (slope, 0.57 ± 0.39, P = 0.15). Conclusions: Focal capillary densities were significantly associated with a wider range of visual field losses and in a larger proportion of the visual field compared to nerve fiber thickness.
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