Evidence map›Paper›PMID 33372841›Full record

ArticleVirulence2021

Cross-protective immunity of the haemagglutinin stalk domain presented on the surface of

Han Lei, Tong Gao, Qianhong Cen

Open access · goldAbstract read
In one paragraph

Article in Virulence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Pharmaceutics · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Han LeiCollege of Medicine, Southwest Jiaotong University , Chengdu, China.
Tong GaoCollege of Medicine, Southwest Jiaotong University , Chengdu, China.
Qianhong CenCollege of Medicine, Southwest Jiaotong University , Chengdu, China.
Southwest Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most of the current approaches to influenza vaccine design focus on antibodies against influenza (HA). However, these influenza vaccines typically provide strain-specific protection against mostly homologous subtypes. There is an urgent need to develop a universal vaccine that confers cross-protection against influenza viruses. Of note, the HA stalk domain (HAsd) is a promising target for such an influenza vaccine. In this study, we generated recombinant

Indexed as

Administration, OralAnimalsAntibodies, ViralCross ProtectionFemaleHemagglutinins, ViralImmunogenicity, VaccineInfluenza A virusInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza A Virus, H5N1 SubtypeInfluenza VaccinesLactococcus lactisMiceMice, Inbred BALB COrthomyxoviridae InfectionsAntibodies, ViralHemagglutinins, ViralInfluenza VaccinesVaccines, Syntheticcross-protectioninfluenza A virusesL. lactis/pNZ8150-pgsA-HAsd

Identifiers

PMID33372841
PMCPMC7781637
OpenAlexW3116634011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.