Evidence map›Paper›PMID 33372528›Full record

ArticleJournal of the American Heart Association2021

Genetic Liability to Depression and Risk of Coronary Artery Disease, Myocardial Infarction, and Other Cardiovascular Outcomes.

Yunlong Lu, Zhen Wang, Marios K Georgakis, Hefeng Lin, Liangrong Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 8 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 8 syntheses or guidelines pooled it, 105 citations in OpenAlex.

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  4. Identification ofDepression and anxiety · 2025
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Yunlong LuDepartment of Cardiology School of Medicine The First Affiliated HospitalZhejiang University Hangzhou Zhejiang China.
Zhen WangDepartment of Cardiology School of Medicine The First Affiliated HospitalZhejiang University Hangzhou Zhejiang China.
Marios K GeorgakisInstitute for Stroke and Dementia Research (ISD) University HospitalLudwig-Maximilians-University LMU Munich Germany.
Hefeng LinThe First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang China.
Liangrong ZhengDepartment of Cardiology School of Medicine The First Affiliated HospitalZhejiang University Hangzhou Zhejiang China.
First Affiliated Hospital Zhejiang University · CNLudwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Observational studies have indicated that depression is associated with coronary artery disease (CAD) and myocardial infarction. Nevertheless, causal associations between depression and cardiovascular diseases remain controversial. Hence, we conducted a Mendelian randomization and mediation analysis to evaluate the associations of depression-related genetic variants with CAD and myocardial infarction. Methods and Results Summary statistics from genome-wide association studies of depression (807 553 individuals), and CAD (60 801 cases, including 43 676 with myocardial infarction, and 123 504 controls) were used. We pooled Mendelian randomization estimates using a fixed-effects inverse-variance weighted meta-analysis and multivariable Mendelian randomization. The mediation effects of potential cardiovascular risk factors on depression-CAD and myocardial infarction risk were investigated by using mediation analysis. We also explored the relationship of genetic liability to depression with heart failure, atrial fibrillation, and ischemic stroke. Genetic liability to depression was associated with higher CAD (odds ratio [OR], 1.14; 95% CI, 1.06-1.24;

Indexed as

Coronary Artery DiseaseDepressionMyocardial InfarctionCausalityDiabetes Mellitus, Type 2Genetic Predisposition to DiseaseGenome-Wide Association StudyHeart Disease Risk FactorsHumansMediation AnalysisMendelian Randomization AnalysisPolymorphism, Single NucleotideRisk AssessmentSmokingcardiovascular diseasecoronary artery diseasedepressionMendelian randomizationmyocardial infarction

Identifiers

PMID33372528
PMCPMC7955472
OpenAlexW3116775856

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.