ArticleProceedings of the National Academy of Sciences of the United States of America2021
Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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54citing papers in PubMed, 1 pooled it
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Immunoregulatory mechanisms between epithelial clear cells and mononuclear phagocytes in the epididymis.Andrology · 2024Pooled it
- IsEuropean journal of nuclear medicine and molecular imaging · 2026Trial
- Single-cell immune atlas of mouse testes unveils metabolic reprogramming of FOLR2 + macrophages in orchestrating testicular immunity during aging.GeroScience · 2026Article
- Localisation of immune cell populations during human fetal testicular development.Reproduction & fertility · 2026Article
- Severe fever with thrombocytopenia syndrome virus infection of the male reproductive tract induces pathology and inflammation.Nature microbiology · 2026Article
- Depletion of CX3CR1Mucosal immunology · 2026Article
- Immunological dynamics of the epididymis: from experimental insights to clinical translation.Reproduction & fertility · 2026Review
- Macrophages regulate meiotic initiation and germ cell clearance in the developing ovary.bioRxiv : the preprint server for biology · 2026Article
- Targeting the CMKLR1-Mediated Signaling Rebalances Immunometabolism State in Middle-Age Testicular Macrophages.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Epididymal macrophage senescence contributes to sperm motility decrease upon environmental stress.Science advances · 2026Article
- Common Environmental Hazards and Male Infertility: Effects on Epididymal Immune Microenvironment.Toxics · 2026Review
- 25HC regulates the polarization of CD163Frontiers in immunology · 2026Article
- Article
- Article
- Acidic Offense: Proton-secreting Cells Orchestrate Inflammation and Sperm Damage in Epididymitis.Function (Oxford, England) · 2025Article
- Macrophage transition to a myofibroblast state drives fibrotic disease in uropathogenic E. coli-induced epididymo-orchitis.The Journal of clinical investigation · 2025Article
- The RNF8/OPTN/KDM6A axis controls macrophage polarization to maintain testicular microenvironment homeostasis.Cell death discovery · 2025Article
- Spatio-Temporal Dynamics of MBulletin of mathematical biology · 2025Article
- A Single-Cell Transcriptome Atlas Characterizes the Immune Landscape of Human Testes During Aging.Aging cell · 2025Article
- Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review).Molecular medicine reports · 2025Review
Corrections and comments
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Authors and funding
30 authors at 9 institutions in 6 countries.
Ming WangMedical Research Center, The First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, China.ORCID 0000-0002-4913-5390
Yalong YangInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0002-4167-3311
Dilay CanseverInstitute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland.
Yiming WangToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada.
Crystal KantoresToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada.
Sébastien MessiaenLaboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells, and Radiation, UMR E008, Commissariat à l'Energie Atomique/Direction de la Recherche Fondamentale/Institut de Biologie François Jacob/Institut de Radiobiologie Cellulaire et Moléculaire, University of Paris, University Paris-Saclay, Fontenay aux Roses F-92265, France.
Delphine MoisonLaboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells, and Radiation, UMR E008, Commissariat à l'Energie Atomique/Direction de la Recherche Fondamentale/Institut de Biologie François Jacob/Institut de Radiobiologie Cellulaire et Moléculaire, University of Paris, University Paris-Saclay, Fontenay aux Roses F-92265, France.
Gabriel LiveraLaboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells, and Radiation, UMR E008, Commissariat à l'Energie Atomique/Direction de la Recherche Fondamentale/Institut de Biologie François Jacob/Institut de Radiobiologie Cellulaire et Moléculaire, University of Paris, University Paris-Saclay, Fontenay aux Roses F-92265, France.
Svetoslav ChakarovSingapore Immunology Network, Agency for Science, Technology and Research (A*STAR) BIOPOLIS, 138648 Singapore, Singapore.
Tobias WeinbergerMedizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität Klinikum, Ludwig-Maximilians-Universität, 81377 Munich, Germany.ORCID 0000-0003-0024-020X
Christopher StremmelMedizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität Klinikum, Ludwig-Maximilians-Universität, 81377 Munich, Germany.ORCID 0000-0002-6404-1421
Monika FijakInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0002-7384-3872
Britta KleinInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0001-7892-069X
Christiane PleugerInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0002-2807-7048
Zhexiong LianChronic Disease Laboratory, Institutes for Life Sciences and School of Medicine, South China University of Technology, 510006 Guangzhou, China.
Wentao MaChronic Disease Laboratory, Institutes for Life Sciences and School of Medicine, South China University of Technology, 510006 Guangzhou, China.
Qingzhi LiuChronic Disease Laboratory, Institutes for Life Sciences and School of Medicine, South China University of Technology, 510006 Guangzhou, China.
Kathrin KleeGenomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany.ORCID 0000-0003-2408-1282
Kristian HändlerSystems Medicine, German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
Thomas UlasGenomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany.ORCID 0000-0002-9785-4197
Andreas SchlitzerQuantitative Systems Biology Life & Medical Sciences Institute, University of Bonn, Carl Troll Strasse 31, 53115 Bonn, Germany.
Joachim L SchultzeGenomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany.
Burkhard BecherInstitute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0002-1541-7867
Melanie GreterInstitute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland.
Zhaoyuan LiuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.ORCID 0000-0002-3117-0833
Florent GinhouxSingapore Immunology Network, Agency for Science, Technology and Research (A*STAR) BIOPOLIS, 138648 Singapore, Singapore.
Slava EpelmanToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada.ORCID 0000-0003-3400-4475
Christian SchulzMedizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität Klinikum, Ludwig-Maximilians-Universität, 81377 Munich, Germany.
Andreas MeinhardtInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, 35392 Giessen, Germany; Andreas.Meinhardt@anatomie.med.uni-giessen.de sudhanshu.bhushan@anatomie.med.uni-giessen.de.
Sudhanshu BhushanInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, 35392 Giessen, Germany; Andreas.Meinhardt@anatomie.med.uni-giessen.de sudhanshu.bhushan@anatomie.med.uni-giessen.de.ORCID 0000-0002-9088-8108
Justus-Liebig-Universität Gießen · DEUniversity of Bonn · DEDirection de la Recherche Fondamentale · FRGerman Centre for Cardiovascular Research · DESouth China University of Technology · CNUniversity Health Network · CAUniversity of Zurich · CHAgency for Science, Technology and Research · SGShanghai Jiao Tong University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophages are the principal immune cells of the epididymis and testis, but their origins, heterogeneity, development, and maintenance are not well understood. Here, we describe distinct populations of epididymal and testicular macrophages that display an organ-specific cellular identity. Combining in vivo fate-mapping, chimeric and parabiotic mouse models with in-depth cellular analyses, we found that CD64
Indexed as
AnimalsCell DifferentiationCell LineageEpididymisInfertility, MaleMacrophagesMaleMiceMice, Inbred C57BLMonocytesTestisepididymismacrophgaesmonocytesontogenytestis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.