Evidence map›Paper›PMID 33372138›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

T

Fengyin Li, Xin Zhao, Yali Zhang, Peng Shao, Xiaoke Ma, William J Paradee, Chengyu Liu, Jianmin Wang, Hai-Hui Xue

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
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  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
  14. Functional analysis ofFrontiers in medicine · 2023
    Article
  15. Review
  16. Tumor immune checkpoints and their associated inhibitors.Journal of Zhejiang University. Science. B · 2022
    Review
  17. Article
  18. Article
  19. TCF1 in T cell immunity: a broadened frontier.Nature reviews. Immunology · 2022
    Review
  20. Contribution of Dendritic Cell Subsets to T Cell-Dependent Responses in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Fengyin LiDepartment of Rheumatology and Immunology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, People's Republic of China; fyli88@ustc.edu.cn jianmin.wang@roswellpark.org haihui.xue@hmh-cdi.org.ORCID 0000-0003-4881-3281
Xin ZhaoCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ 07110.ORCID 0000-0002-9303-7675
Yali ZhangDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263.
Peng ShaoDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.ORCID 0000-0002-8453-6480
Xiaoke MaSchool of Computer Science and Technology, Xidian University, 215123 Xi'an, Shanxi, People's Republic of China.ORCID 0000-0002-5604-7137
William J ParadeeGenome Editing Core Facility, University of Iowa, Coralville, IA 52241.
Chengyu LiuTransgenic Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Jianmin WangDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263; fyli88@ustc.edu.cn jianmin.wang@roswellpark.org haihui.xue@hmh-cdi.org.ORCID 0000-0001-7527-0409
Hai-Hui XueCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ 07110; fyli88@ustc.edu.cn jianmin.wang@roswellpark.org haihui.xue@hmh-cdi.org.
University of Iowa · USRoswell Park Comprehensive Cancer Center · USHackensack University Medical Center · USNational Institutes of Health · USUniversity of Science and Technology of China · CNXidian University · CN

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
Transgenic CoreZICHL005907 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LIU, CHENGYU · 2010 to 2025
$25.8M
Tcf/Lef-b-catenin in T cell identity and cancerR01AI112579 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2015 to 2026
$5.4M
Tcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6M
Ezh2 regulates follicular helper T cell differentiationR01AI139874 · NIAID · UNIVERSITY OF IOWA · PI PENG, WEIQUN, XUE, HAI-HUI · 2018 to 2022
$2.4M
Targeting Tcf/Lef-transcriptional program in leukemic stem cellsI01BX002903 · VA · VA NEW JERSEY HEALTH CARE SYSTEM · PI XUE, HAI-HUI · 2016 to 2019
–
BLRD VA I01 BX002903NCI NIH HHS P30 CA016056NIAID NIH HHS R01 AI112579NIAID NIH HHS R01 AI121080NIAID NIH HHS R01 AI139874
6 · The paper itself

Abstract

Precise regulation of coinhibitory receptors is essential for maintaining immune tolerance without interfering with protective immunity, yet the mechanism underlying such a balanced act remains poorly understood. In response to protein immunization, T follicular helper (T

Indexed as

AnimalsAntigens, CDB-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCTLA-4 AntigenFemaleGerminal CenterHepatocyte Nuclear Factor 1-alphaImmune ToleranceLymphocyte Activation Gene 3 ProteinLymphoid Enhancer-Binding Factor 1MaleMiceMice, Inbred C57BLProto-Oncogene Proteins c-bcl-6Antigens, CDBcl6 protein, mouseCTLA-4 AntigenCtla4 protein, mouseHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseLag3 protein, mouseLef1 protein, mouseLymphocyte Activation Gene 3 ProteinLymphoid Enhancer-Binding Factor 1Proto-Oncogene Proteins c-bcl-6coinhibitory pathwayfollicular helper T cellstranscriptional regulation

Identifiers

PMID33372138
PMCPMC7812797
OpenAlexW3114133415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.