ArticleProceedings of the National Academy of Sciences of the United States of America2021
Mechanisms and plasticity of chemogenically induced interneuronal suppression of principal cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Dentate gyrus interneurons modulate winner-take-all network dynamics in freely behaving mice.Neuron · 2026Article
- Maternal Stress Primes Adolescent Stress Susceptibility via Microglial Complement-Dependent Synaptic Phagocytosis.Research (Washington, D.C.) · 2026Article
- Optogenetic stimulation of memory-tagged neurons elicits endogenous patterns of neural activity.bioRxiv : the preprint server for biology · 2025Article
- AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice.Communications biology · 2025Article
- Cathodal weak direct current decreases epileptic excitability with reduced neuronal activity and enhanced delta oscillations.The Journal of physiology · 2025Article
- Mapping global brain reconfigurations following local targeted manipulations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dentate gyrus is needed for memory retrieval.Molecular psychiatry · 2024Article
- Article
- Adolescents rats engage the orbitofrontal-striatal pathway differently than adults during impulsive actions.Scientific reports · 2024Article
- Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice.Nature communications · 2024Article
- Perturbing cortical networks:Frontiers in neuroscience · 2024Article
- Hippocampal sharp-wave ripples and their spike assembly content are regulated by the medial entorhinal cortex.Current biology : CB · 2023Article
- Synaptogenic gene therapy with FGF22 improves circuit plasticity and functional recovery following spinal cord injury.EMBO molecular medicine · 2023Article
- Inhibitory conductance controls place field dynamics in the hippocampus.Cell reports · 2022Article
- Applications of chemogenetics in non-human primates.Current opinion in pharmacology · 2022Review
- Brain temperature affects quantitative features of hippocampal sharp wave ripples.Journal of neurophysiology · 2022Article
- Review
- Article
- Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action.Cell reports · 2021Article
- Metal microdrive and head cap system for silicon probe recovery in freely moving rodent.eLife · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
How do firing patterns in a cortical circuit change when inhibitory neurons are excited? We virally expressed an excitatory designer receptor exclusively activated by a designer drug (Gq-DREADD) in all inhibitory interneuron types of the CA1 region of the hippocampus in the rat. While clozapine N-oxide (CNO) activation of interneurons suppressed firing of pyramidal cells, unexpectedly the majority of interneurons also decreased their activity. CNO-induced inhibition decreased over repeated sessions, which we attribute to long-term synaptic plasticity between interneurons and pyramidal cells. Individual interneurons did not display sustained firing but instead transiently enhanced their activity, interleaved with suppression of others. The power of the local fields in the theta band was unaffected, while power at higher frequencies was attenuated, likely reflecting reduced pyramidal neuron spiking. The incidence of sharp wave ripples decreased but the surviving ripples were associated with stronger population firing compared with the control condition. These findings demonstrate that DREADD activation of interneurons brings about both short-term and long-term circuit reorganization, which should be taken into account in the interpretation of chemogenic effects on behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.