Evidence map›Paper›PMID 33372108›Full record

ArticleJournal of investigative medicine : the official publication of the American Federation for Clinical Research2020

Single-cell transcriptomics analysis showing functional heterogeneity in decidual stromal cells during labor.

Jingrui Huang, Yingming Xie, Qiaozhen Peng, Weinan Wang, Chenlin Pei, Yanhua Zhao, Rong Liu, Lihui Huang, Tieping Li, Jia Nie and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Decidualization and Related Pregnancy Complications.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Jingrui HuangDepartment of Obstetrics, Xiangya Hospital Central South University, Changsha, Hunan, China.
Yingming XieDepartment of Obstetrics, Xiangya Hospital Central South University, Changsha, Hunan, China.
Qiaozhen PengDepartment of Obstetrics, Xiangya Hospital Central South University, Changsha, Hunan, China.
Weinan WangDepartment of Obstetrics, Xiangya Hospital Central South University, Changsha, Hunan, China.
Chenlin PeiDepartment of Obstetrics, Xiangya Hospital Central South University, Changsha, Hunan, China.
Yanhua ZhaoDepartment of Obstetrics, Xiangya Hospital Central South University, Changsha, Hunan, China.
Rong LiuDepartment of Obstetrics, Xiangya Hospital Central South University, Changsha, Hunan, China.
Lihui HuangDepartment of Obstetrics and Gynecology, Changsha Hospital for Maternal and Child Health Care, Changsha, Hunan, China.
Tieping LiDepartment of Obstetrics and Gynecology, Changsha Hospital for Maternal and Child Health Care, Changsha, Hunan, China.
Jia NieDepartment of Obstetrics, Xiangya Hospital Central South University, Changsha, Hunan, China.
Lijuan LiuDepartment of Obstetrics, Xiangya Hospital Central South University, Changsha, Hunan, China.
Xiaowen ZhangDepartment of Obstetrics, Xiangya Hospital Central South University, Changsha, Hunan, China.
Xianggui LuoDepartment of Obstetrics, Xiangya Hospital Central South University, Changsha, Hunan, China.
Jiefeng LuoDepartment of Obstetrics, Xiangya Hospital Central South University, Changsha, Hunan, China.
Weishe ZhangDepartment of Obstetrics, Xiangya Hospital Central South University, Changsha, Hunan, China weishezhang@csu.edu.cn.ORCID http://orcid.org/0000-0002-1633-0587
Central South University · CNChangsha Hospital for Maternal and Child Health Care · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the heterogeneity of decidual stromal cells (DSCs) and their functional alterations during delivery, we conducted single-cell RNA sequencing analysis to characterize the transcriptomic profiles of DSCs before and after labor onset. According to their transcriptomic profiles, DSCs (6382 cells) were clustered into five subgroups with different functions. Similar to stromal cells, cells in cluster 1 were involved in cell substrate adhesion. On the other hand, cells in clusters 2 and 3 were enriched in signal transduction-related genes. Labor onset led to significant alterations in many pathways, including the activator protein 1 pathway (all clusters), as well as in the response to lipopolysaccharide (clusters 1-3). The downregulated genes were involved in coagulation, ATP synthesis, and oxygen homeostasis, possibly reflecting the oxygen and energy balance during delivery. Our findings highlight that peripartum DSCs are heterogeneous and play multiple roles in labor.

Indexed as

deliveryobstetric

Identifiers

PMID33372108
PMCPMC8020081
OpenAlexW3114729459

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.