Evidence map›Paper›PMID 33372060›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

NMDA Receptor Enhances Correlation of Spontaneous Activity in Neonatal Barrel Cortex.

Hidenobu Mizuno, Madhura S Rao, Hiromi Mizuno, Takuya Sato, Shingo Nakazawa, Takuji Iwasato

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hidenobu MizunoLaboratory of Multi-Dimensional Imaging, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto 860-0811, Japan hmizuno@kumamoto-u.ac.jp.ORCID 0000-0001-6262-7106
Madhura S RaoLaboratory of Multi-Dimensional Imaging, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto 860-0811, Japan.ORCID 0000-0002-7198-9739
Hiromi MizunoLaboratory of Multi-Dimensional Imaging, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto 860-0811, Japan.
Takuya SatoLaboratory of Mammalian Neural Circuits, National Institute of Genetics, Mishima 411-8540, Japan.
Shingo NakazawaLaboratory of Mammalian Neural Circuits, National Institute of Genetics, Mishima 411-8540, Japan.ORCID 0000-0003-0673-5641
Takuji IwasatoLaboratory of Mammalian Neural Circuits, National Institute of Genetics, Mishima 411-8540, Japan.ORCID 0000-0002-4514-6324
Kumamoto University · JPNational Institute of Genetics · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Correlated spontaneous activity plays critical role in the organization of neocortical circuits during development. However, cortical mechanisms regulating activity correlation are still elusive. In this study, using two-photon calcium imaging of the barrel cortex layer 4 (L4) in living neonatal mice, we found that NMDA receptors (NMDARs) in L4 neurons are important for enhancement of spontaneous activity correlation. Disruption of GluN1 (

Indexed as

AnimalsAnimals, NewbornExcitatory Postsynaptic PotentialsFemaleMaleMiceMice, 129 StrainMice, Inbred C57BLMice, Inbred ICRMice, KnockoutMolecular ImagingNerve Tissue ProteinsReceptors, N-Methyl-D-AspartateSomatosensory CortexGprin1 protein, mouseNerve Tissue ProteinsReceptors, N-Methyl-D-Aspartatebarrel cortexin vivo two-photon calcium imagingL4 neuronsNMDA receptorsparse cell labelingspontaneous activity correlation

Identifiers

PMID33372060
PMCPMC7888224
OpenAlexW3117691674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.