Evidence map›Paper›PMID 33371897›Full record

ArticleCell communication and signaling : CCS2020

Calcium mediated functional interplay between myocardial cells upon laser-induced single-cell injury: an in vitro study of cardiac cell death signaling mechanisms.

Krishna Chander Sridhar, Nils Hersch, Georg Dreissen, Rudolf Merkel, Bernd Hoffmann

Open access · goldAbstract read
In one paragraph

Article in Cell communication and signaling : CCS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Krishna Chander SridharInstitute of Biological Information Processing, IBI-2: Mechanobiology, Forschungszentrum Jülich, 52425, Jülich, Germany.
Nils HerschInstitute of Biological Information Processing, IBI-2: Mechanobiology, Forschungszentrum Jülich, 52425, Jülich, Germany.
Georg DreissenInstitute of Biological Information Processing, IBI-2: Mechanobiology, Forschungszentrum Jülich, 52425, Jülich, Germany.
Rudolf MerkelInstitute of Biological Information Processing, IBI-2: Mechanobiology, Forschungszentrum Jülich, 52425, Jülich, Germany.
Bernd HoffmannInstitute of Biological Information Processing, IBI-2: Mechanobiology, Forschungszentrum Jülich, 52425, Jülich, Germany. b.hoffmann@fz-juelich.de.ORCID http://orcid.org/0000-0002-3803-8835
Forschungszentrum Jülich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe electromechanical function of myocardial tissue depends on the intercellular communication between cardiomyocytes (CMs) as well as their crosstalk with other cell types. Cell injury, and subsequent death trigger inflammation as in myocardial infarction (MI) resulting in myocardial remodeling. Although mechanisms underlying myocardial cell death have been studied so far, the signaling events following single cell death and spontaneous response of connected cells in the myocardial tissue is still barely understood.

methodsHere, we investigated the effect of laser-induced single cell death on Calcium (Ca

resultsCell death triggered spontaneous increase in intracellular Ca

conclusionsThese findings illustrate the spontaneous Ca

Indexed as

LasersSignal TransductionSingle-Cell AnalysisAnimalsCalciumCell DeathCells, CulturedDiffusionFluorescenceGap JunctionsLiposomesMyocardiumMyocytes, CardiacRatsCalciumLiposomesCalcium transportCardiac fibroblastCardiomyocyteGap junctionInduced cell deathLaser ablationMyocardial infarction

Identifiers

PMID33371897
PMCPMC7771078
OpenAlexW3114872849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.