Evidence map›Paper›PMID 33371773›Full record

ArticleAdipocyte2021

Characterization of the adiponectin promoter + Cre recombinase insertion in the Tg(Adipoq-cre)1Evdr mouse by targeted locus amplification and droplet digital PCR.

Adrian M Wong, Tushar P Patel, Elizabeth K Altman, Nicol Tugarinov, Giampaolo Trivellin, Jack A Yanovski

Open access · goldAbstract read
In one paragraph

Article in Adipocyte, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Transgene Mapping in Animals: What to Choose?International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. The widely usedbioRxiv : the preprint server for biology · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Adrian M WongSection on Growth and Obesity and Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health , Bethesda, MD, USA.ORCID 0000-0003-3919-0705
Tushar P PatelSection on Growth and Obesity and Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health , Bethesda, MD, USA.ORCID 0000-0002-7823-2579
Elizabeth K AltmanSection on Growth and Obesity and Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health , Bethesda, MD, USA.ORCID 0000-0002-4185-5203
Nicol TugarinovSection on Growth and Obesity and Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health , Bethesda, MD, USA.ORCID 0000-0003-0918-9172
Giampaolo TrivellinSection on Genetics and Endocrinology, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health , Bethesda, MD, USA.ORCID 0000-0003-2384-4153
Jack A YanovskiSection on Growth and Obesity and Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health , Bethesda, MD, USA.ORCID 0000-0001-8542-1637
National Institutes of Health · US

Funding

Physiology, Psychology, and Genetics of ObesityZIAHD000641 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YANOVSKI, JACK A. · 2009 to 2025
$24.8M
Intramural NIH HHS ZIA HD000641
6 · The paper itself

Abstract

The Tg(Adipoq-cre)1Evdr mouse has become an important tool in adipose tissue biology. However, the exact genomic transgene integration site has not been established. Using Targeted Locus Amplification (TLA) we found the transgene had integrated on mouse chromosome 9 between exons 6 and 7 of

Indexed as

AdiponectinAdipose TissueAnimalsGene ExpressionIntegrasesMiceMice, TransgenicModels, AnimalOrgan SpecificityPolymerase Chain ReactionPromoter Regions, GeneticT-Box Domain ProteinsTransgenesAdiponectinCre recombinaseIntegrasesT-Box Domain ProteinsTbx18 protein, mouseadipocyteAdiponectinadipose tissueinsertion pointtissue-specific gene expressiontransgenic mouse

Identifiers

PMID33371773
PMCPMC7781622
OpenAlexW3114077992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.