Evidence map›Paper›PMID 33371330›Full record

ArticleJournal of clinical medicine2020

Orthostatic Headache in Children Including Postural Tachycardia Syndrome and Orthostatic Hypotension: A Near-Infrared Spectroscopy Study.

Soken Go, Gaku Yamanaka, Akiko Kasuga, Kanako Kanou, Tomoko Takamatsu, Mika Takeshita, Natsumi Morishita, Shinichiro Morichi, Yu Ishida, Shingo Oana and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Treatment of Headache in Children and Adolescents with POTS.Current pain and headache reports · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Headache and Autonomic Dysfunction: a Review.Current neurology and neuroscience reports · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Soken GoDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.ORCID 0000-0003-0940-0273
Gaku YamanakaDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.
Akiko KasugaDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.
Kanako KanouDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.
Tomoko TakamatsuDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.
Mika TakeshitaDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.
Natsumi MorishitaDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.
Shinichiro MorichiDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.ORCID 0000-0001-9790-9808
Yu IshidaDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.
Shingo OanaDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.
Yasuyo KashiwagiDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.
Takashi MitsufujiDepartment of Neurology, Saitama Medical University, Saitama 350-0495, Japan.
Nobuo ArakiDepartment of Neurology, Saitama Medical University, Saitama 350-0495, Japan.
Hisashi KawashimaDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.
Tokyo Medical University · JPSaitama Medical University · JP

Funding

Japan Agency for Medical Research and Development JP19dk0310099
6 · The paper itself

Abstract

BACKGROUND AND

aimAlthough head and/or neck pain attributed to orthostatic hypotension is included in international guidelines, its mechanisms and relevance remain unknown. This study examined the term's relevance and aimed to elucidate the associated clinical features.

methodsAn active stand test was performed to evaluate fluctuations in systemic and cerebral circulation in children and adolescents reporting complaints in the absence of a confirmed organic disorder. The subjects were categorized based on orthostatic headache presence/absence, and their characteristics and test results were compared.

resultsPostural tachycardia syndrome was observed in 50.0% of children with, and 55.1% without, orthostatic headache. For orthostatic hypotension, the respective values were 31.3% and 30.6%. A history of migraine was more prevalent in children with orthostatic headaches (64.1% vs. 28.6%;

conclusionFluctuations in cerebral blood flow were associated with orthostatic headaches in children, suggesting that the headaches are due to impaired intracranial homeostasis. As orthostatic headache can have multiple causes, the term "head and/or neck pain attributed to orthostatic (postural) hypotension" should be replaced with a more inclusive term.

Indexed as

active standing testadolescentcerebral blood flow fluctuationcerebrospinal fluid leakchildrenheadachehead and/or neck painhead up-tiltmigraineorthostatic dysregulationorthostatic headacheorthostatic intolerancepediatricpostural tachycardia syndromethe International Classification of Headache Disorders 3rd edition

Identifiers

PMID33371330
PMCPMC7767397
OpenAlexW3115995221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.