Evidence map›Paper›PMID 33371319›Full record

ArticleInternational journal of molecular sciences2020

The Histamine 3 Receptor Is Expressed in the Heart and Its Activation Opposes Adverse Cardiac Remodeling in the Angiotensin II Mouse Model.

Samuel L McCaffrey, Grace Lim, Martyn Bullock, Ainsley O Kasparian, Roderick Clifton-Bligh, William B Campbell, Alexander Widiapradja, Scott P Levick

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Role of Dopamine in the Heart in Health and Disease.International journal of molecular sciences · 2023
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Samuel L McCaffreyKolling Institute for Medical Research, Royal North Shore Hospital, St Leonards, NSW 2064, Australia.
Grace LimKolling Institute for Medical Research, Royal North Shore Hospital, St Leonards, NSW 2064, Australia.
Martyn BullockKolling Institute for Medical Research, Royal North Shore Hospital, St Leonards, NSW 2064, Australia.ORCID 0000-0002-3740-5509
Ainsley O KasparianKolling Institute for Medical Research, Royal North Shore Hospital, St Leonards, NSW 2064, Australia.
Roderick Clifton-BlighKolling Institute for Medical Research, Royal North Shore Hospital, St Leonards, NSW 2064, Australia.
William B CampbellDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Alexander WidiapradjaKolling Institute for Medical Research, Royal North Shore Hospital, St Leonards, NSW 2064, Australia.
Scott P LevickKolling Institute for Medical Research, Royal North Shore Hospital, St Leonards, NSW 2064, Australia.ORCID 0000-0001-5034-4942
Royal North Shore Hospital · AUThe University of Sydney · AUMedical College of Wisconsin · USUniversity of Technology Sydney · AU

Funding

Substance P: A central mediator of cardiac fibrosis and diastolic dysfunctionR01HL132908 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI CAMPBELL, WILLIAM BRYSON · 2017 to 2020
$1.4M
Substance P: A central mediator of cardiac fibrosis and diastolic dysfunctionR56HL132908 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI LEVICK, SCOTT P · 2016 to 2016
$385k
NHLBI NIH HHS HL132908NHLBI NIH HHS R01 HL132908
6 · The paper itself

Abstract

Histamine is a basic amine stored in mast cells, with its release capable of activating one of four histamine receptors. The histamine 3 receptor (H

Indexed as

Disease Models, AnimalAngiotensin IIAnimalsFibrosisInflammationMaleMiceMice, Inbred C57BLRatsRats, Sprague-DawleyReceptors, Histamine H3Ventricular RemodelingAngiotensin IIReceptors, Histamine H3A331440collagenextracellular matrixfibroblastfibrosishistamine receptor agonisthistamine receptor antagonistimetitmacrophagemast cell

Identifiers

PMID33371319
PMCPMC7767352
OpenAlexW3118063655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.