Evidence map›Paper›PMID 33371260›Full record

ReviewBrain sciences2020

Relevance and Clinical Significance of Magnetic Resonance Imaging of Neurological Manifestations in COVID-19: A Systematic Review of Case Reports and Case Series.

Anisa Chowdhary, Roshan Subedi, Medha Tandon, Sijin Wen, Jenil Patel, Saurabh Kataria, Sarah Peterson, Ronald Gwinn, Mahmoud Elkhooly, Apoorv Prasad and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Neurologic and Neuromuscular Sequelae of COVID-19.Physical medicine and rehabilitation clinics of North America · 2023
    Review
  4. Central nervous system outcomes of COVID-19.Translational research : the journal of laboratory and clinical medicine · 2022
    Review
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Anisa ChowdharyInstitute of Nuclear Medicine and Allied Sciences, New Delhi 110054, India.ORCID 0000-0001-7935-7229
Roshan SubediInstitute of Medicine, Kathmandu P.O.BOX 1524, Nepal.ORCID 0000-0002-8279-4777
Medha TandonSafdarjung Hospital, New Delhi 110029, India.ORCID 0000-0003-1818-2669
Sijin WenDepartment of Biostatistics, West Virginia University, Morgantown, WV 26506, USA.
Jenil PatelDepartment of Epidemiology, Fay W. Boozman, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.ORCID 0000-0002-4875-7390
Saurabh KatariaDepartment of Neurology, University of Missouri Healthcare, Columbia, MO 65212, USA.ORCID 0000-0001-8104-3085
Sarah PetersonSchool of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Ronald GwinnSchool of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Mahmoud ElkhoolyDepartment of Neuropsychiatry, Minia University, Minia 61519, Egypt.ORCID 0000-0002-1299-3906
Apoorv PrasadDepartment of Neurology, Berkeley Medical Center, West Virginia University, Morgantown, WV 26506, USA.
Lalit NirwanMeditrina Institute of Medical Sciences, Nagpur, Maharashtra 440012, India.ORCID 0000-0003-3089-2903
Amelia AdcockDepartment of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.
Shitiz SriwastavaDepartment of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.
West Virginia University · USInstitute of Medical Sciences · INInstitute of Nuclear Medicine & Allied Sciences · INMinia University · EGSafdarjang Hospital · INUniversity of Arkansas for Medical Sciences · USUniversity of Missouri Health System · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Laura F. Gibson · 2012 to 2026
$81.0M
NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

We performed a systematic literature review of neuroimaging, predominantly focusing on magnetic resonance imaging (MRI) findings associated with neurological manifestations of coronavirus disease-2019 (COVID-19). We screened articles from PubMed, Google Scholar and Scopus, looking for reports that would potentially have neuroimaging findings in patients with COVID-19. Data analysis was performed with patient-based data based on the availability of clinical characteristics and outcomes for each individual patient from the studies. Chi square and Wilcoxon rank-sum tests were used to report COVID-19 severity and outcomes based on neurological imaging indicators and pathophysiology. A total of 171 patients with COVID-19 having neurological complications, from 134 studies, were identified in our review. The most common neuroimaging finding was ischemic stroke (62, 36.2%) cases, followed by CNS inflammatory disorder (44, 25.7%), and hemorrhagic stroke (41, 24.0%). Around 51% of all the fatal COVID-19 cases had an ischemic stroke. Among patients with ischemic stroke, the mean age of those who suffered from COVID-19 infection was 57.5 years (SD = 15.4) whereas it was 50.7 years (SD = 15.1) among those without stroke/other diagnosis. Fatality was more common in patients with ischemic stroke compared to those with other diagnosis (40% vs. 22%,

Indexed as

COVID-19MRI in COVID-19neuroimaging in COVID-19SARS CoV-2stroke

Identifiers

PMID33371260
PMCPMC7766893
OpenAlexW3118209077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.